Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

A delay in T cell responses is postulated as a possible explanation for the limited efficacy of vaccines against tuberculosis. Here the authors demonstrate this T-cell block and remove it by activating endogenous dendritic cells or delivering activated dendritic cells to the lungs, enhancing immunit...

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Autores principales:	Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd3ed674f11f4ebeb8f3cd4244067e57
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spelling	oai:doaj.org-article:dd3ed674f11f4ebeb8f3cd4244067e572021-12-02T14:40:13ZTargeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy10.1038/ncomms138942041-1723https://doaj.org/article/dd3ed674f11f4ebeb8f3cd4244067e572016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13894https://doaj.org/toc/2041-1723A delay in T cell responses is postulated as a possible explanation for the limited efficacy of vaccines against tuberculosis. Here the authors demonstrate this T-cell block and remove it by activating endogenous dendritic cells or delivering activated dendritic cells to the lungs, enhancing immunity of mice toMycobacterium tuberculosis.Kristin L. GriffithsMushtaq AhmedShibali DasRadha GopalWilliam HorneTerry D. ConnellKelly D. MoynihanJay K. KollsDarrell J. IrvineMaxim N. ArtyomovJavier Rangel-MorenoShabaana A. KhaderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristin L. Griffiths Mushtaq Ahmed Shibali Das Radha Gopal William Horne Terry D. Connell Kelly D. Moynihan Jay K. Kolls Darrell J. Irvine Maxim N. Artyomov Javier Rangel-Moreno Shabaana A. Khader Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
description	A delay in T cell responses is postulated as a possible explanation for the limited efficacy of vaccines against tuberculosis. Here the authors demonstrate this T-cell block and remove it by activating endogenous dendritic cells or delivering activated dendritic cells to the lungs, enhancing immunity of mice toMycobacterium tuberculosis.
format	article
author	Kristin L. Griffiths Mushtaq Ahmed Shibali Das Radha Gopal William Horne Terry D. Connell Kelly D. Moynihan Jay K. Kolls Darrell J. Irvine Maxim N. Artyomov Javier Rangel-Moreno Shabaana A. Khader
author_facet	Kristin L. Griffiths Mushtaq Ahmed Shibali Das Radha Gopal William Horne Terry D. Connell Kelly D. Moynihan Jay K. Kolls Darrell J. Irvine Maxim N. Artyomov Javier Rangel-Moreno Shabaana A. Khader
author_sort	Kristin L. Griffiths
title	Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
title_short	Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
title_full	Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
title_fullStr	Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
title_full_unstemmed	Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
title_sort	targeting dendritic cells to accelerate t-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dd3ed674f11f4ebeb8f3cd4244067e57
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Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

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