Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy

Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owne...

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Autores principales:	Rikako Asada, Satoshi Mizuno, Yoshihiko Yu, Yuji Hamamoto, Tetsuya Anazawa, Daisuke Ito, Masato Kitagawa, Daisuke Hasegawa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	corpus callosotomy dog drug-resistant epilepsy epilepsy surgery veterinary Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/dd411e34ec1a43a88e15a64cbe6fdadf
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spelling	oai:doaj.org-article:dd411e34ec1a43a88e15a64cbe6fdadf2021-11-25T16:57:51ZCorpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy10.3390/brainsci111114622076-3425https://doaj.org/article/dd411e34ec1a43a88e15a64cbe6fdadf2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1462https://doaj.org/toc/2076-3425Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine.Rikako AsadaSatoshi MizunoYoshihiko YuYuji HamamotoTetsuya AnazawaDaisuke ItoMasato KitagawaDaisuke HasegawaMDPI AGarticlecorpus callosotomydogdrug-resistant epilepsyepilepsy surgeryveterinaryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1462, p 1462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corpus callosotomy dog drug-resistant epilepsy epilepsy surgery veterinary Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	corpus callosotomy dog drug-resistant epilepsy epilepsy surgery veterinary Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
description	Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine.
format	article
author	Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa
author_facet	Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa
author_sort	Rikako Asada
title	Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_short	Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_full	Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_fullStr	Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_full_unstemmed	Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_sort	corpus callosotomy in 3 cavalier king charles spaniel dogs with drug-resistant epilepsy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dd411e34ec1a43a88e15a64cbe6fdadf
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Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy

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