Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

Abstract Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa...

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Autores principales:	Jean Joel Bigna, Joel Noutakdie Tochie, Dahlia Noelle Tounouga, Anne Olive Bekolo, Nadia S. Ymele, Emilie Lettitia Youda, Paule Sandra Sime, Jobert Richie Nansseu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd41987863bb42c4a76b496ffd070ad0
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spelling	oai:doaj.org-article:dd41987863bb42c4a76b496ffd070ad02021-12-02T17:55:13ZGlobal, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis10.1038/s41598-020-69078-92045-2322https://doaj.org/article/dd41987863bb42c4a76b496ffd070ad02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69078-9https://doaj.org/toc/2045-2322Abstract Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7–2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8–5.5) and The Americas, the lowest (1.1%, 0.8–1.4), with a statistically significant difference between WHO regions (p < 0.0001). The global IgG seroprevalence was 32.9% (95%CI: 29.4–36.4). Among WHO regions, The Americas had the highest prevalence (45.2%, 95%CI: 33.4–53.4) and Western Pacific the lowest (11.2%, 7.8–15.1), with a statistically significant difference between regions (p < 0.0001). This study presents a high toxoplasma seropositivity in pregnant women at global, regional and country levels, with a consequential high risk of maternal and congenital toxoplasmosis.Jean Joel BignaJoel Noutakdie TochieDahlia Noelle TounougaAnne Olive BekoloNadia S. YmeleEmilie Lettitia YoudaPaule Sandra SimeJobert Richie NansseuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean Joel Bigna Joel Noutakdie Tochie Dahlia Noelle Tounouga Anne Olive Bekolo Nadia S. Ymele Emilie Lettitia Youda Paule Sandra Sime Jobert Richie Nansseu Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
description	Abstract Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7–2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8–5.5) and The Americas, the lowest (1.1%, 0.8–1.4), with a statistically significant difference between WHO regions (p < 0.0001). The global IgG seroprevalence was 32.9% (95%CI: 29.4–36.4). Among WHO regions, The Americas had the highest prevalence (45.2%, 95%CI: 33.4–53.4) and Western Pacific the lowest (11.2%, 7.8–15.1), with a statistically significant difference between regions (p < 0.0001). This study presents a high toxoplasma seropositivity in pregnant women at global, regional and country levels, with a consequential high risk of maternal and congenital toxoplasmosis.
format	article
author	Jean Joel Bigna Joel Noutakdie Tochie Dahlia Noelle Tounouga Anne Olive Bekolo Nadia S. Ymele Emilie Lettitia Youda Paule Sandra Sime Jobert Richie Nansseu
author_facet	Jean Joel Bigna Joel Noutakdie Tochie Dahlia Noelle Tounouga Anne Olive Bekolo Nadia S. Ymele Emilie Lettitia Youda Paule Sandra Sime Jobert Richie Nansseu
author_sort	Jean Joel Bigna
title	Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
title_short	Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
title_full	Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
title_fullStr	Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
title_full_unstemmed	Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
title_sort	global, regional, and country seroprevalence of toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dd41987863bb42c4a76b496ffd070ad0
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Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

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