Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.

<h4>Objective</h4>To investigate the association between the nuclear factor kappa B (NF-kB) gene polymorphism and age-related macular degeneration (AMD) in a high-altitude population.<h4>Methods</h4>Fifty-five patients with AMD and 57 control subjects were recruited from the...

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Autores principales:	Yan Xin, Kang Zefeng, Li Ling, Guan Ruijuan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd43917afe954382b8c7c923e9e512b4
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spelling	oai:doaj.org-article:dd43917afe954382b8c7c923e9e512b42021-12-02T20:03:54ZAssociation between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.1932-620310.1371/journal.pone.0251931https://doaj.org/article/dd43917afe954382b8c7c923e9e512b42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251931https://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate the association between the nuclear factor kappa B (NF-kB) gene polymorphism and age-related macular degeneration (AMD) in a high-altitude population.<h4>Methods</h4>Fifty-five patients with AMD and 57 control subjects were recruited from the Qinghai Provincial People's Hospital, China. Genomic DNA was extracted from the blood sample of each participant. Four NF-kB polymorphisms (rs3774959, rs3774932, rs3774937, and rs230526) were genotyped using a MassARRAY system. The genotype and allele frequencies were compared between the case and control groups using the chi-squared test or Fisher's exact test.<h4>Results</h4>There was no significant difference in sex, age, hypertension, diabetes, blood lipid level or smoking and drinking status between the AMD and control groups (P > 0.05). The genotype distributions of four NF-kB polymorphisms were in accordance with Hardy-Weinberg equilibrium in the control group (P > 0.05). The frequencies of genotype AA of rs3774932 and genotype CC of rs3774937 were nominally significantly higher in the AMD group than in the control group (P = 0.046 and 0.023, respectively), although these associations did not survive the Bonferroni correction (corrected P > 0.05). Genotype distributions of rs3774959 and rs230526 were not significantly different between the two groups (P = 0.08 and 0.16, respectively). No significant difference in the allele frequencies of the four polymorphisms was found between the AMD and control groups (P > 0.05).<h4>Conclusions</h4>Genotype AA of rs3774932 and genotype CC of rs3774937 in NF-kB might be risk factors for AMD.Yan XinKang ZefengLi LingGuan RuijuanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0251931 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Xin Kang Zefeng Li Ling Guan Ruijuan Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
description	<h4>Objective</h4>To investigate the association between the nuclear factor kappa B (NF-kB) gene polymorphism and age-related macular degeneration (AMD) in a high-altitude population.<h4>Methods</h4>Fifty-five patients with AMD and 57 control subjects were recruited from the Qinghai Provincial People's Hospital, China. Genomic DNA was extracted from the blood sample of each participant. Four NF-kB polymorphisms (rs3774959, rs3774932, rs3774937, and rs230526) were genotyped using a MassARRAY system. The genotype and allele frequencies were compared between the case and control groups using the chi-squared test or Fisher's exact test.<h4>Results</h4>There was no significant difference in sex, age, hypertension, diabetes, blood lipid level or smoking and drinking status between the AMD and control groups (P > 0.05). The genotype distributions of four NF-kB polymorphisms were in accordance with Hardy-Weinberg equilibrium in the control group (P > 0.05). The frequencies of genotype AA of rs3774932 and genotype CC of rs3774937 were nominally significantly higher in the AMD group than in the control group (P = 0.046 and 0.023, respectively), although these associations did not survive the Bonferroni correction (corrected P > 0.05). Genotype distributions of rs3774959 and rs230526 were not significantly different between the two groups (P = 0.08 and 0.16, respectively). No significant difference in the allele frequencies of the four polymorphisms was found between the AMD and control groups (P > 0.05).<h4>Conclusions</h4>Genotype AA of rs3774932 and genotype CC of rs3774937 in NF-kB might be risk factors for AMD.
format	article
author	Yan Xin Kang Zefeng Li Ling Guan Ruijuan
author_facet	Yan Xin Kang Zefeng Li Ling Guan Ruijuan
author_sort	Yan Xin
title	Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
title_short	Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
title_full	Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
title_fullStr	Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
title_full_unstemmed	Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.
title_sort	association between nf-kb polymorphism and age-related macular degeneration in a high-altitude population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd43917afe954382b8c7c923e9e512b4
work_keys_str_mv	AT yanxin associationbetweennfkbpolymorphismandagerelatedmaculardegenerationinahighaltitudepopulation AT kangzefeng associationbetweennfkbpolymorphismandagerelatedmaculardegenerationinahighaltitudepopulation AT liling associationbetweennfkbpolymorphismandagerelatedmaculardegenerationinahighaltitudepopulation AT guanruijuan associationbetweennfkbpolymorphismandagerelatedmaculardegenerationinahighaltitudepopulation
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Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.

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