The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-stru...
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Nature Portfolio
2018
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oai:doaj.org-article:dd48eac540f1490a9bb31a4f740711ca2021-12-02T16:57:00ZThe genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma10.1038/s41467-018-04448-62041-1723https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04448-6https://doaj.org/toc/2041-1723Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.Bill H. DiplasXujun HeJacqueline A. Brosnan-CashmanHeng LiuLee H. ChenZhaohui WangCasey J. MourePatrick J. KillelaDaniel B. LoriauxEric S. LippPaula K. GreerRui YangAnthony J. RizzoFausto J. RodriguezAllan H. FriedmanHenry S. FriedmanSizhen WangYiping HeRoger E. McLendonDarell D. BignerYuchen JiaoMatthew S. WaitkusAlan K. MeekerHai YanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Bill H. Diplas Xujun He Jacqueline A. Brosnan-Cashman Heng Liu Lee H. Chen Zhaohui Wang Casey J. Moure Patrick J. Killela Daniel B. Loriaux Eric S. Lipp Paula K. Greer Rui Yang Anthony J. Rizzo Fausto J. Rodriguez Allan H. Friedman Henry S. Friedman Sizhen Wang Yiping He Roger E. McLendon Darell D. Bigner Yuchen Jiao Matthew S. Waitkus Alan K. Meeker Hai Yan The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| description |
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1. |
| format |
article |
| author |
Bill H. Diplas Xujun He Jacqueline A. Brosnan-Cashman Heng Liu Lee H. Chen Zhaohui Wang Casey J. Moure Patrick J. Killela Daniel B. Loriaux Eric S. Lipp Paula K. Greer Rui Yang Anthony J. Rizzo Fausto J. Rodriguez Allan H. Friedman Henry S. Friedman Sizhen Wang Yiping He Roger E. McLendon Darell D. Bigner Yuchen Jiao Matthew S. Waitkus Alan K. Meeker Hai Yan |
| author_facet |
Bill H. Diplas Xujun He Jacqueline A. Brosnan-Cashman Heng Liu Lee H. Chen Zhaohui Wang Casey J. Moure Patrick J. Killela Daniel B. Loriaux Eric S. Lipp Paula K. Greer Rui Yang Anthony J. Rizzo Fausto J. Rodriguez Allan H. Friedman Henry S. Friedman Sizhen Wang Yiping He Roger E. McLendon Darell D. Bigner Yuchen Jiao Matthew S. Waitkus Alan K. Meeker Hai Yan |
| author_sort |
Bill H. Diplas |
| title |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| title_short |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| title_full |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| title_fullStr |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| title_full_unstemmed |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma |
| title_sort |
genomic landscape of tert promoter wildtype-idh wildtype glioblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca |
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