Clinicopathological Analysis and Demographic Features of Ocular Malignancies

Clinicopathological Analysis and Demographic Features of Ocular Malignancies

Abdullah Al-Mujaini,1 Rajendra Prakash Maurya,2 Sanjay Bosak,2 Manish Kumar Karan,2 Meghna Roy,2 Virendra Pratap Singh,2 Mahendra Kumar Singh,2 Ajay Kumar,3 Samer Singh4 1Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Sultan Qaboos University...

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Autores principales: Al-Mujaini A, Maurya RP, Bosak S, Karan MK, Roy M, Singh VP, Singh MK, Kumar A, Singh S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
ocular malignancy
tumors
diagnosis
primary cancer
sebaceous gland carcinoma
neoadjuvant chemotherapy.
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/dd4bd93efa6d499e81b55081d9de9c44
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spelling oai:doaj.org-article:dd4bd93efa6d499e81b55081d9de9c442021-12-02T14:17:44ZClinicopathological Analysis and Demographic Features of Ocular Malignancies1177-5483https://doaj.org/article/dd4bd93efa6d499e81b55081d9de9c442021-01-01T00:00:00Zhttps://www.dovepress.com/clinicopathological-analysis-andnbspdemographic-features-of-ocular-mal-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Abdullah Al-Mujaini,1 Rajendra Prakash Maurya,2 Sanjay Bosak,2 Manish Kumar Karan,2 Meghna Roy,2 Virendra Pratap Singh,2 Mahendra Kumar Singh,2 Ajay Kumar,3 Samer Singh4 1Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman; 2Regional Institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; 3Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India; 4Centre for Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaCorrespondence: Rajendra Prakash Maurya; Samer Singh Email mauryarp_bhu@yahoo.com; samersingh@gmail.comObjective: This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India.Methods: A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed.Results: Overall, males over 55 years of age were most commonly affected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence.Conclusion: A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.Keywords: ocular malignancy, tumors, diagnosis, primary cancer, sebaceous gland carcinoma, neoadjuvant chemotherapyAl-Mujaini AMaurya RPBosak SKaran MKRoy MSingh VPSingh MKKumar ASingh SDove Medical Pressarticleocular malignancytumorsdiagnosisprimary cancersebaceous gland carcinomaneoadjuvant chemotherapy.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 357-365 (2021)
institution DOAJ
collection DOAJ
language EN
topic ocular malignancy
tumors
diagnosis
primary cancer
sebaceous gland carcinoma
neoadjuvant chemotherapy.
Ophthalmology
RE1-994
spellingShingle ocular malignancy
tumors
diagnosis
primary cancer
sebaceous gland carcinoma
neoadjuvant chemotherapy.
Ophthalmology
RE1-994
Al-Mujaini A
Maurya RP
Bosak S
Karan MK
Roy M
Singh VP
Singh MK
Kumar A
Singh S
Clinicopathological Analysis and Demographic Features of Ocular Malignancies
description Abdullah Al-Mujaini,1 Rajendra Prakash Maurya,2 Sanjay Bosak,2 Manish Kumar Karan,2 Meghna Roy,2 Virendra Pratap Singh,2 Mahendra Kumar Singh,2 Ajay Kumar,3 Samer Singh4 1Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman; 2Regional Institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; 3Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India; 4Centre for Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaCorrespondence: Rajendra Prakash Maurya; Samer Singh Email mauryarp_bhu@yahoo.com; samersingh@gmail.comObjective: This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India.Methods: A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed.Results: Overall, males over 55 years of age were most commonly affected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence.Conclusion: A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.Keywords: ocular malignancy, tumors, diagnosis, primary cancer, sebaceous gland carcinoma, neoadjuvant chemotherapy
format article
author Al-Mujaini A
Maurya RP
Bosak S
Karan MK
Roy M
Singh VP
Singh MK
Kumar A
Singh S
author_facet Al-Mujaini A
Maurya RP
Bosak S
Karan MK
Roy M
Singh VP
Singh MK
Kumar A
Singh S
author_sort Al-Mujaini A
title Clinicopathological Analysis and Demographic Features of Ocular Malignancies
title_short Clinicopathological Analysis and Demographic Features of Ocular Malignancies
title_full Clinicopathological Analysis and Demographic Features of Ocular Malignancies
title_fullStr Clinicopathological Analysis and Demographic Features of Ocular Malignancies
title_full_unstemmed Clinicopathological Analysis and Demographic Features of Ocular Malignancies
title_sort clinicopathological analysis and demographic features of ocular malignancies
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/dd4bd93efa6d499e81b55081d9de9c44
work_keys_str_mv AT almujainia clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
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AT bosaks clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
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AT roym clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
AT singhvp clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
AT singhmk clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
AT kumara clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
AT singhs clinicopathologicalanalysisandnbspdemographicfeaturesofocularmalignancies
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