Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.

<h4>Background</h4>Leprosy is potentially debilitating. The risk factors related to physical disabilities associated with leprosy disease in Yunnan, China was not clear.<h4>Methodology/principal findings</h4>We studied 10644 newly detected leprosy patients from Yunnan, China,...

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Autores principales:	Xiaohua Chen, Hong-Bing Liu, Tie-Jun Shui, Shun Zha
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/dd4e69b509784ec48c3c35714632a864
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spelling	oai:doaj.org-article:dd4e69b509784ec48c3c35714632a8642021-12-02T20:23:31ZRisk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.1935-27271935-273510.1371/journal.pntd.0009923https://doaj.org/article/dd4e69b509784ec48c3c35714632a8642021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009923https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Leprosy is potentially debilitating. The risk factors related to physical disabilities associated with leprosy disease in Yunnan, China was not clear.<h4>Methodology/principal findings</h4>We studied 10644 newly detected leprosy patients from Yunnan, China, from 1990 to 2019. Factors associated with Grade 1 (G1D) and Grade 2 (G2D) physical disabilities or overall physical disabilities (combined G1D and G2D) associated with leprosy were analyzed using multinomial and ordinal logistic regression analyses. The following factors were associated with the development of physical disability in these patients with leprosy: delayed diagnosis [odds ratio (OR): 5.652, 4.399, and 2.275; 95% confidence intervals (CIs): 4.516-7.073, 3.714-5.212, and 2.063-2.509; for ≥ 10, 5-10 y, and 2-5 years, respectively], nerve damage (OR: 3.474 and 2.428; 95% CI: 2.843-4.244, and 1.959-3.008; for 2 and 1 damaged nerves, respectively), WHO classification of PB (OR: 1.759; 95% CI: 1.341-2.307), Ridley-Jopling classification (OR: 1.479, 1.438, 1.522 and 1.239; 95% CI: 1.052-2.079, 1.075-1.923, 1.261-1.838, and 1.072-1.431; for TT, BT, BB, and BL when compared with LL, respectively), advanced age (OR: 1.472 and 2.053; 95% CI: 1.106-1.960 and 1.498-2.814; for 15-59 and over 60 years old, respectively), zero skin lesions (OR: 1.916; 95% CI: 1.522-2.413), leprosy reaction (OR: 1.528; 95% CI: 1.195-1.952), rural occupation (OR: 1.364; 95% CI: 1.128-1.650), Han ethnicity (OR: 1.268; 95% CI: 1.159-1.386), and male sex (OR: 1.128; 95% CI: 1.024-1.243).<h4>Conclusions</h4>Delayed diagnosis, nerve damage, no skin lesions, WHO and Ridley-Jopling classifications, leprosy reactions, advanced age, rural occupation, Han ethnicity, and male sex were associated with disability in leprosy patients. Identifying risk factors could help to prevent physical disability.Xiaohua ChenHong-Bing LiuTie-Jun ShuiShun ZhaPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009923 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xiaohua Chen Hong-Bing Liu Tie-Jun Shui Shun Zha Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
description	<h4>Background</h4>Leprosy is potentially debilitating. The risk factors related to physical disabilities associated with leprosy disease in Yunnan, China was not clear.<h4>Methodology/principal findings</h4>We studied 10644 newly detected leprosy patients from Yunnan, China, from 1990 to 2019. Factors associated with Grade 1 (G1D) and Grade 2 (G2D) physical disabilities or overall physical disabilities (combined G1D and G2D) associated with leprosy were analyzed using multinomial and ordinal logistic regression analyses. The following factors were associated with the development of physical disability in these patients with leprosy: delayed diagnosis [odds ratio (OR): 5.652, 4.399, and 2.275; 95% confidence intervals (CIs): 4.516-7.073, 3.714-5.212, and 2.063-2.509; for ≥ 10, 5-10 y, and 2-5 years, respectively], nerve damage (OR: 3.474 and 2.428; 95% CI: 2.843-4.244, and 1.959-3.008; for 2 and 1 damaged nerves, respectively), WHO classification of PB (OR: 1.759; 95% CI: 1.341-2.307), Ridley-Jopling classification (OR: 1.479, 1.438, 1.522 and 1.239; 95% CI: 1.052-2.079, 1.075-1.923, 1.261-1.838, and 1.072-1.431; for TT, BT, BB, and BL when compared with LL, respectively), advanced age (OR: 1.472 and 2.053; 95% CI: 1.106-1.960 and 1.498-2.814; for 15-59 and over 60 years old, respectively), zero skin lesions (OR: 1.916; 95% CI: 1.522-2.413), leprosy reaction (OR: 1.528; 95% CI: 1.195-1.952), rural occupation (OR: 1.364; 95% CI: 1.128-1.650), Han ethnicity (OR: 1.268; 95% CI: 1.159-1.386), and male sex (OR: 1.128; 95% CI: 1.024-1.243).<h4>Conclusions</h4>Delayed diagnosis, nerve damage, no skin lesions, WHO and Ridley-Jopling classifications, leprosy reactions, advanced age, rural occupation, Han ethnicity, and male sex were associated with disability in leprosy patients. Identifying risk factors could help to prevent physical disability.
format	article
author	Xiaohua Chen Hong-Bing Liu Tie-Jun Shui Shun Zha
author_facet	Xiaohua Chen Hong-Bing Liu Tie-Jun Shui Shun Zha
author_sort	Xiaohua Chen
title	Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
title_short	Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
title_full	Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
title_fullStr	Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
title_full_unstemmed	Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
title_sort	risk factors for physical disability in patients with leprosy disease in yunnan, china: evidence from a retrospective observational study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd4e69b509784ec48c3c35714632a864
work_keys_str_mv	AT xiaohuachen riskfactorsforphysicaldisabilityinpatientswithleprosydiseaseinyunnanchinaevidencefromaretrospectiveobservationalstudy AT hongbingliu riskfactorsforphysicaldisabilityinpatientswithleprosydiseaseinyunnanchinaevidencefromaretrospectiveobservationalstudy AT tiejunshui riskfactorsforphysicaldisabilityinpatientswithleprosydiseaseinyunnanchinaevidencefromaretrospectiveobservationalstudy AT shunzha riskfactorsforphysicaldisabilityinpatientswithleprosydiseaseinyunnanchinaevidencefromaretrospectiveobservationalstudy
_version_	1718374137766871040

Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.

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