Choriocapillaris microvasculature dysfunction in systemic hypertension

Abstract We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine...

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Autores principales:	Jacqueline Chua, Thu-Thao Le, Bingyao Tan, Mengyuan Ke, Chi Li, Damon Wing Kee Wong, Anna C. S. Tan, Ecosse Lamoureux, Tien Yin Wong, Calvin Woon Loong Chin, Leopold Schmetterer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd503c0b3ac84f63b8aed1958faeedca
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spelling	oai:doaj.org-article:dd503c0b3ac84f63b8aed1958faeedca2021-12-02T15:54:06ZChoriocapillaris microvasculature dysfunction in systemic hypertension10.1038/s41598-021-84136-62045-2322https://doaj.org/article/dd503c0b3ac84f63b8aed1958faeedca2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84136-6https://doaj.org/toc/2045-2322Abstract We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm2; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm2; 3551 ± 41) and healthy controls (365 ± 11 µm2; 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease.Jacqueline ChuaThu-Thao LeBingyao TanMengyuan KeChi LiDamon Wing Kee WongAnna C. S. TanEcosse LamoureuxTien Yin WongCalvin Woon Loong ChinLeopold SchmettererNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jacqueline Chua Thu-Thao Le Bingyao Tan Mengyuan Ke Chi Li Damon Wing Kee Wong Anna C. S. Tan Ecosse Lamoureux Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer Choriocapillaris microvasculature dysfunction in systemic hypertension
description	Abstract We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm2; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm2; 3551 ± 41) and healthy controls (365 ± 11 µm2; 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease.
format	article
author	Jacqueline Chua Thu-Thao Le Bingyao Tan Mengyuan Ke Chi Li Damon Wing Kee Wong Anna C. S. Tan Ecosse Lamoureux Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer
author_facet	Jacqueline Chua Thu-Thao Le Bingyao Tan Mengyuan Ke Chi Li Damon Wing Kee Wong Anna C. S. Tan Ecosse Lamoureux Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer
author_sort	Jacqueline Chua
title	Choriocapillaris microvasculature dysfunction in systemic hypertension
title_short	Choriocapillaris microvasculature dysfunction in systemic hypertension
title_full	Choriocapillaris microvasculature dysfunction in systemic hypertension
title_fullStr	Choriocapillaris microvasculature dysfunction in systemic hypertension
title_full_unstemmed	Choriocapillaris microvasculature dysfunction in systemic hypertension
title_sort	choriocapillaris microvasculature dysfunction in systemic hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd503c0b3ac84f63b8aed1958faeedca
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Choriocapillaris microvasculature dysfunction in systemic hypertension

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