Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/dd521bbbf78046d888ba049b54d46e2e |
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oai:doaj.org-article:dd521bbbf78046d888ba049b54d46e2e2021-12-02T15:34:50ZMacrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice10.1038/ncomms133442041-1723https://doaj.org/article/dd521bbbf78046d888ba049b54d46e2e2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13344https://doaj.org/toc/2041-1723Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors.Gustavo MonneratMicaela L. AlarcónLuiz R. VasconcellosCamila Hochman-MendezGuilherme BrasilRosana A. BassaniOscar CasisDaniela MalanLeonardo H. TravassosMarisa SepúlvedaJuan Ignacio BurgosMartin Vila-PetroffFabiano F. DutraMarcelo T. BozzaClaudia N. PaivaAdriana Bastos CarvalhoAdriana BonomoBernd K. FleischmannAntonio Carlos Campos de CarvalhoEmiliano MedeiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q |
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Science Q Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| description |
Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors. |
| format |
article |
| author |
Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei |
| author_facet |
Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei |
| author_sort |
Gustavo Monnerat |
| title |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_short |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_fullStr |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full_unstemmed |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_sort |
macrophage-dependent il-1β production induces cardiac arrhythmias in diabetic mice |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/dd521bbbf78046d888ba049b54d46e2e |
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