Canine D163-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context

Canine D163-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context

Abstract E/D163 polymorphism of dog prion protein (PrP) has been recently proposed as the variant responsible for canid prion resistance. To further investigate the protective role of this variant against prion replication, the transgenic mouse model OvPrP-Tg532 expressing sheep/goat PrP carrying th...

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Autores principales: Alba Marín-Moreno, Juan Carlos Espinosa, Patricia Aguilar-Calvo, Natalia Fernández-Borges, José Luis Pitarch, Lorenzo González, Juan María Torres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/dd52988c19cf4e058e4786fdf4f8fbf6
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