GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

Hepatic gluconeogenesis is tightly regulated at transcriptional level and is essential for survival during prolonged fasting. Here Wang et al. show that the mitochondrial enriched GCN5-like 1 protein controls hepatic glucose production by regulating FoxO1 protein levels via proteasome-dependent degr...

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Autores principales:	Lingdi Wang, Iain Scott, Lu Zhu, Kaiyuan Wu, Kim Han, Yong Chen, Marjan Gucek, Michael N. Sack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd536fabc4864be3a3421f03e7c771de
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spelling	oai:doaj.org-article:dd536fabc4864be3a3421f03e7c771de2021-12-02T14:41:09ZGCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis10.1038/s41467-017-00521-82041-1723https://doaj.org/article/dd536fabc4864be3a3421f03e7c771de2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00521-8https://doaj.org/toc/2041-1723Hepatic gluconeogenesis is tightly regulated at transcriptional level and is essential for survival during prolonged fasting. Here Wang et al. show that the mitochondrial enriched GCN5-like 1 protein controls hepatic glucose production by regulating FoxO1 protein levels via proteasome-dependent degradation and, in turn, gluconeogenic gene expression.Lingdi WangIain ScottLu ZhuKaiyuan WuKim HanYong ChenMarjan GucekMichael N. SackNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingdi Wang Iain Scott Lu Zhu Kaiyuan Wu Kim Han Yong Chen Marjan Gucek Michael N. Sack GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
description	Hepatic gluconeogenesis is tightly regulated at transcriptional level and is essential for survival during prolonged fasting. Here Wang et al. show that the mitochondrial enriched GCN5-like 1 protein controls hepatic glucose production by regulating FoxO1 protein levels via proteasome-dependent degradation and, in turn, gluconeogenic gene expression.
format	article
author	Lingdi Wang Iain Scott Lu Zhu Kaiyuan Wu Kim Han Yong Chen Marjan Gucek Michael N. Sack
author_facet	Lingdi Wang Iain Scott Lu Zhu Kaiyuan Wu Kim Han Yong Chen Marjan Gucek Michael N. Sack
author_sort	Lingdi Wang
title	GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
title_short	GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
title_full	GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
title_fullStr	GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
title_full_unstemmed	GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis
title_sort	gcn5l1 modulates cross-talk between mitochondria and cell signaling to regulate foxo1 stability and gluconeogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dd536fabc4864be3a3421f03e7c771de
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GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

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