Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster

Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster

Abstract Aggregates of amyloid-β (Aβ) peptide are well known to be the causative substance of Alzheimer’s disease (AD). Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Aβ peptide responsible for the onset and development of AD. Howeve...

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Autores principales: Yuhei Tachi, Yuko Okamoto, Hisashi Okumura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/dd56961f09d24c21b1d253dd95928a15
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