Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster

Abstract Aggregates of amyloid-β (Aβ) peptide are well known to be the causative substance of Alzheimer’s disease (AD). Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Aβ peptide responsible for the onset and development of AD. Howeve...

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Détails bibliographiques
Auteurs principaux: Yuhei Tachi, Yuko Okamoto, Hisashi Okumura
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/dd56961f09d24c21b1d253dd95928a15
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