TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-TRIB3 interaction attenuates NSCLC progression by a...

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Autores principales:	Jiao-jiao Yu, Dan-dan Zhou, Xiao-xiao Yang, Bing Cui, Feng-wei Tan, Junjian Wang, Ke Li, Shuang Shang, Cheng Zhang, Xiao-xi Lv, Xiao-wei Zhang, Shan-shan Liu, Jin-mei Yu, Feng Wang, Bo Huang, Fang Hua, Zhuo-Wei Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd56caddb5794e359d42000db61b7459
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spelling	oai:doaj.org-article:dd56caddb5794e359d42000db61b74592021-12-02T17:55:14ZTRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target10.1038/s41467-020-17385-02041-1723https://doaj.org/article/dd56caddb5794e359d42000db61b74592020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17385-0https://doaj.org/toc/2041-1723Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-TRIB3 interaction attenuates NSCLC progression by accelerating EGFR degradation.Jiao-jiao YuDan-dan ZhouXiao-xiao YangBing CuiFeng-wei TanJunjian WangKe LiShuang ShangCheng ZhangXiao-xi LvXiao-wei ZhangShan-shan LiuJin-mei YuFeng WangBo HuangFang HuaZhuo-Wei HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiao-jiao Yu Dan-dan Zhou Xiao-xiao Yang Bing Cui Feng-wei Tan Junjian Wang Ke Li Shuang Shang Cheng Zhang Xiao-xi Lv Xiao-wei Zhang Shan-shan Liu Jin-mei Yu Feng Wang Bo Huang Fang Hua Zhuo-Wei Hu TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
description	Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-TRIB3 interaction attenuates NSCLC progression by accelerating EGFR degradation.
format	article
author	Jiao-jiao Yu Dan-dan Zhou Xiao-xiao Yang Bing Cui Feng-wei Tan Junjian Wang Ke Li Shuang Shang Cheng Zhang Xiao-xi Lv Xiao-wei Zhang Shan-shan Liu Jin-mei Yu Feng Wang Bo Huang Fang Hua Zhuo-Wei Hu
author_facet	Jiao-jiao Yu Dan-dan Zhou Xiao-xiao Yang Bing Cui Feng-wei Tan Junjian Wang Ke Li Shuang Shang Cheng Zhang Xiao-xi Lv Xiao-wei Zhang Shan-shan Liu Jin-mei Yu Feng Wang Bo Huang Fang Hua Zhuo-Wei Hu
author_sort	Jiao-jiao Yu
title	TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
title_short	TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
title_full	TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
title_fullStr	TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
title_full_unstemmed	TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
title_sort	trib3-egfr interaction promotes lung cancer progression and defines a therapeutic target
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dd56caddb5794e359d42000db61b7459
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TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

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