Squamous Cell Carcinoma: An Update on Diagnosis and Treatment

Squamous cell carcinoma (SCC) accounts for most nonmelanoma skin cancer–related metastatic disease and deaths. Histopathology and correct surgical excision remain the gold standard for the diagnosis and treatment of SCC; however, new diagnostic imaging techniques such as dermoscopy and reflectance...

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Autores principales:	Andrea Combalia, Cristina Carrera
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2020
Materias:	Bowen disease squamous cell carcinoma actinic keratosis cancerization field dermoscopy confocal microscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/dd57300cb62e470b8d6ae142baacb29e
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spelling	oai:doaj.org-article:dd57300cb62e470b8d6ae142baacb29e2021-11-17T08:28:44ZSquamous Cell Carcinoma: An Update on Diagnosis and Treatment10.5826/dpc.1003a662160-9381https://doaj.org/article/dd57300cb62e470b8d6ae142baacb29e2020-06-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1111https://doaj.org/toc/2160-9381 Squamous cell carcinoma (SCC) accounts for most nonmelanoma skin cancer–related metastatic disease and deaths. Histopathology and correct surgical excision remain the gold standard for the diagnosis and treatment of SCC; however, new diagnostic imaging techniques such as dermoscopy and reflectance confocal microscopy have increased the diagnostic accuracy in terms of early recognition, better differential diagnosis, more precise selection of areas to biopsy, and noninvasive monitoring of treatments. The therapeutic intervention in patients with severe actinic damage and multiple in situ/low-risk SCC, and the development of innovative treatments such as epidermal growth factor receptor inhibitors and immune checkpoint inhibitors for locally advanced and metastatic SCC, are improving considerably the approach to the disease. This review summarizes the up-to-date knowledge in the field of detection, treatment, and monitoring of cutaneous SCC. Andrea CombaliaCristina CarreraMattioli1885articleBowen diseasesquamous cell carcinomaactinic keratosiscancerization fielddermoscopyconfocal microscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 10, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bowen disease squamous cell carcinoma actinic keratosis cancerization field dermoscopy confocal microscopy Dermatology RL1-803
spellingShingle	Bowen disease squamous cell carcinoma actinic keratosis cancerization field dermoscopy confocal microscopy Dermatology RL1-803 Andrea Combalia Cristina Carrera Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
description	Squamous cell carcinoma (SCC) accounts for most nonmelanoma skin cancer–related metastatic disease and deaths. Histopathology and correct surgical excision remain the gold standard for the diagnosis and treatment of SCC; however, new diagnostic imaging techniques such as dermoscopy and reflectance confocal microscopy have increased the diagnostic accuracy in terms of early recognition, better differential diagnosis, more precise selection of areas to biopsy, and noninvasive monitoring of treatments. The therapeutic intervention in patients with severe actinic damage and multiple in situ/low-risk SCC, and the development of innovative treatments such as epidermal growth factor receptor inhibitors and immune checkpoint inhibitors for locally advanced and metastatic SCC, are improving considerably the approach to the disease. This review summarizes the up-to-date knowledge in the field of detection, treatment, and monitoring of cutaneous SCC.
format	article
author	Andrea Combalia Cristina Carrera
author_facet	Andrea Combalia Cristina Carrera
author_sort	Andrea Combalia
title	Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
title_short	Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
title_full	Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
title_fullStr	Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
title_full_unstemmed	Squamous Cell Carcinoma: An Update on Diagnosis and Treatment
title_sort	squamous cell carcinoma: an update on diagnosis and treatment
publisher	Mattioli1885
publishDate	2020
url	https://doaj.org/article/dd57300cb62e470b8d6ae142baacb29e
work_keys_str_mv	AT andreacombalia squamouscellcarcinomaanupdateondiagnosisandtreatment AT cristinacarrera squamouscellcarcinomaanupdateondiagnosisandtreatment
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Squamous Cell Carcinoma: An Update on Diagnosis and Treatment

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