A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets.

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Autores principales: Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari, Ying Chen, Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder, Elisa Izaurralde
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dd58df3ad8ed437f920ca025930a2428
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spelling oai:doaj.org-article:dd58df3ad8ed437f920ca025930a24282021-12-02T14:42:04ZA CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin10.1038/ncomms143072041-1723https://doaj.org/article/dd58df3ad8ed437f920ca025930a24282017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14307https://doaj.org/toc/2041-1723Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets.Annamaria SgromoTobias RaischPraveen BawankarDipankar BhandariYing ChenDuygu Kuzuoğlu-ÖztürkOliver WeichenriederElisa IzaurraldeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Annamaria Sgromo
Tobias Raisch
Praveen Bawankar
Dipankar Bhandari
Ying Chen
Duygu Kuzuoğlu-Öztürk
Oliver Weichenrieder
Elisa Izaurralde
A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
description Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets.
format article
author Annamaria Sgromo
Tobias Raisch
Praveen Bawankar
Dipankar Bhandari
Ying Chen
Duygu Kuzuoğlu-Öztürk
Oliver Weichenrieder
Elisa Izaurralde
author_facet Annamaria Sgromo
Tobias Raisch
Praveen Bawankar
Dipankar Bhandari
Ying Chen
Duygu Kuzuoğlu-Öztürk
Oliver Weichenrieder
Elisa Izaurralde
author_sort Annamaria Sgromo
title A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
title_short A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
title_full A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
title_fullStr A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
title_full_unstemmed A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
title_sort caf40-binding motif facilitates recruitment of the ccr4-not complex to mrnas targeted by drosophila roquin
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/dd58df3ad8ed437f920ca025930a2428
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