Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of...

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Autores principales: Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang, Chawnshang Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae6
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spelling oai:doaj.org-article:dd59eae932f04abc982fd88aa1d85ae62021-12-02T17:01:24ZAndrogen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma10.1038/s41467-017-00701-62041-1723https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00701-6https://doaj.org/toc/2041-1723The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.Qingbo HuangYin SunXin MaYu GaoXintao LiYuanjie NiuXu ZhangChawnshang ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
description The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.
format article
author Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
author_facet Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
author_sort Qingbo Huang
title Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_short Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_fullStr Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full_unstemmed Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_sort androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae6
work_keys_str_mv AT qingbohuang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yinsun androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xinma androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yugao androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xintaoli androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yuanjieniu androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xuzhang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT chawnshangchang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
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