Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of...

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Auteurs principaux:	Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang, Chawnshang Chang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae6
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spelling	oai:doaj.org-article:dd59eae932f04abc982fd88aa1d85ae62021-12-02T17:01:24ZAndrogen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma10.1038/s41467-017-00701-62041-1723https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00701-6https://doaj.org/toc/2041-1723The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.Qingbo HuangYin SunXin MaYu GaoXintao LiYuanjie NiuXu ZhangChawnshang ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingbo Huang Yin Sun Xin Ma Yu Gao Xintao Li Yuanjie Niu Xu Zhang Chawnshang Chang Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
description	The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.
format	article
author	Qingbo Huang Yin Sun Xin Ma Yu Gao Xintao Li Yuanjie Niu Xu Zhang Chawnshang Chang
author_facet	Qingbo Huang Yin Sun Xin Ma Yu Gao Xintao Li Yuanjie Niu Xu Zhang Chawnshang Chang
author_sort	Qingbo Huang
title	Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_short	Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full	Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_fullStr	Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full_unstemmed	Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_sort	androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dd59eae932f04abc982fd88aa1d85ae6
work_keys_str_mv	AT qingbohuang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT yinsun androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT xinma androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT yugao androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT xintaoli androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT yuanjieniu androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT xuzhang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma AT chawnshangchang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
_version_	1718382181270683648

Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

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