Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study

Abstract Background The required fluid volume differs among patients with septic shock. Enterocyte injury caused by shock may increase the need for fluid by triggering a systematic inflammatory response or an ischemia-reperfusion injury in the presence of intestinal ischemia/necrosis. This study aim...

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Autores principales:	Haruka Yokoyama, Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Hiroshi Araki, Takashi Egashira, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Tetsuya Hara
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Enterocyte damage Fluid administration Fluid volume Intensive care unit Intestinal fatty acid-binding protein Intestinal mucosal cell Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/dd5c25febeed4bfa8ba617fc063e3ee6
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spelling	oai:doaj.org-article:dd5c25febeed4bfa8ba617fc063e3ee62021-11-28T12:09:45ZAssociation between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study10.1186/s12871-021-01515-21471-2253https://doaj.org/article/dd5c25febeed4bfa8ba617fc063e3ee62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12871-021-01515-2https://doaj.org/toc/1471-2253Abstract Background The required fluid volume differs among patients with septic shock. Enterocyte injury caused by shock may increase the need for fluid by triggering a systematic inflammatory response or an ischemia-reperfusion injury in the presence of intestinal ischemia/necrosis. This study aimed to evaluate the association between enterocyte injury and positive fluid balance in patients with septic shock. Methods This study was a post hoc exploratory analysis of a prospective observational study that assessed the association between serum intestinal fatty acid-binding protein, a biomarker of enterocyte injury, and mortality in patients with septic shock. Intestinal fatty acid-binding protein levels were recorded on intensive care unit admission, and fluid balance was monitored from intensive care unit admission to Day 7. The association between intestinal fatty acid-binding protein levels at admission and the infusion balance during the early period after intensive care unit admission was evaluated. Multiple linear regression analysis, with adjustments for severity score and renal function, was performed. Results Overall, data of 57 patients were analyzed. Logarithmically transformed intestinal fatty acid-binding protein levels were significantly associated with cumulative fluid balance per body weight at 24 and 72 h post-intensive care unit admission both before (Pearson’s r = 0.490 [95% confidence interval: 0.263–0.666]; P < 0.001 and r = 0.479 [95% confidence interval: 0.240–0.664]; P < 0.001, respectively) and after (estimate, 14.4 [95% confidence interval: 4.1–24.7]; P = 0.007 and estimate, 26.9 [95% confidence interval: 11.0–42.7]; P = 0.001, respectively) adjusting for severity score and renal function. Conclusions Enterocyte injury was significantly associated with cumulative fluid balance at 24 and 72 h post-intensive care unit admission. Enterocyte injury in patients with septic shock may be related to excessive fluid accumulation during the early period after intensive care unit admission.Haruka YokoyamaMotohiro SekinoHiroyuki FunaokaShuntaro SatoHiroshi ArakiTakashi EgashiraRintaro YanoSojiro MatsumotoTaiga IchinomiyaUshio HigashijimaTetsuya HaraBMCarticleEnterocyte damageFluid administrationFluid volumeIntensive care unitIntestinal fatty acid-binding proteinIntestinal mucosal cellAnesthesiologyRD78.3-87.3ENBMC Anesthesiology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Enterocyte damage Fluid administration Fluid volume Intensive care unit Intestinal fatty acid-binding protein Intestinal mucosal cell Anesthesiology RD78.3-87.3
spellingShingle	Enterocyte damage Fluid administration Fluid volume Intensive care unit Intestinal fatty acid-binding protein Intestinal mucosal cell Anesthesiology RD78.3-87.3 Haruka Yokoyama Motohiro Sekino Hiroyuki Funaoka Shuntaro Sato Hiroshi Araki Takashi Egashira Rintaro Yano Sojiro Matsumoto Taiga Ichinomiya Ushio Higashijima Tetsuya Hara Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
description	Abstract Background The required fluid volume differs among patients with septic shock. Enterocyte injury caused by shock may increase the need for fluid by triggering a systematic inflammatory response or an ischemia-reperfusion injury in the presence of intestinal ischemia/necrosis. This study aimed to evaluate the association between enterocyte injury and positive fluid balance in patients with septic shock. Methods This study was a post hoc exploratory analysis of a prospective observational study that assessed the association between serum intestinal fatty acid-binding protein, a biomarker of enterocyte injury, and mortality in patients with septic shock. Intestinal fatty acid-binding protein levels were recorded on intensive care unit admission, and fluid balance was monitored from intensive care unit admission to Day 7. The association between intestinal fatty acid-binding protein levels at admission and the infusion balance during the early period after intensive care unit admission was evaluated. Multiple linear regression analysis, with adjustments for severity score and renal function, was performed. Results Overall, data of 57 patients were analyzed. Logarithmically transformed intestinal fatty acid-binding protein levels were significantly associated with cumulative fluid balance per body weight at 24 and 72 h post-intensive care unit admission both before (Pearson’s r = 0.490 [95% confidence interval: 0.263–0.666]; P < 0.001 and r = 0.479 [95% confidence interval: 0.240–0.664]; P < 0.001, respectively) and after (estimate, 14.4 [95% confidence interval: 4.1–24.7]; P = 0.007 and estimate, 26.9 [95% confidence interval: 11.0–42.7]; P = 0.001, respectively) adjusting for severity score and renal function. Conclusions Enterocyte injury was significantly associated with cumulative fluid balance at 24 and 72 h post-intensive care unit admission. Enterocyte injury in patients with septic shock may be related to excessive fluid accumulation during the early period after intensive care unit admission.
format	article
author	Haruka Yokoyama Motohiro Sekino Hiroyuki Funaoka Shuntaro Sato Hiroshi Araki Takashi Egashira Rintaro Yano Sojiro Matsumoto Taiga Ichinomiya Ushio Higashijima Tetsuya Hara
author_facet	Haruka Yokoyama Motohiro Sekino Hiroyuki Funaoka Shuntaro Sato Hiroshi Araki Takashi Egashira Rintaro Yano Sojiro Matsumoto Taiga Ichinomiya Ushio Higashijima Tetsuya Hara
author_sort	Haruka Yokoyama
title	Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
title_short	Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
title_full	Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
title_fullStr	Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
title_full_unstemmed	Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
title_sort	association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dd5c25febeed4bfa8ba617fc063e3ee6
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Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study

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