Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprot...

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Autores principales:	Seyedeh M. Zekavat, Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, Jason Ernst, Mark Chaffin, Jesse Engreitz, Gina M. Peloso, Ani Manichaikul, Chaojie Yang, Kathleen A. Ryan, Mao Fu, W. Craig Johnson, Michael Tsai, Matthew Budoff, Ramachandran S. Vasan, L. Adrienne Cupples, Jerome I. Rotter, Stephen S. Rich, Wendy Post, Braxton D. Mitchell, Adolfo Correa, Andres Metspalu, James G. Wilson, Veikko Salomaa, Manolis Kellis, Mark J. Daly, Benjamin M. Neale, Steven McCarroll, Ida Surakka, Tonu Esko, Andrea Ganna, Samuli Ripatti, Sekar Kathiresan, Pradeep Natarajan, NHLBI TOPMed Lipids Working Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd61e81e8545472a93ddce68c769d81d
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spelling	oai:doaj.org-article:dd61e81e8545472a93ddce68c769d81d2021-12-02T15:34:22ZDeep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries10.1038/s41467-018-04668-w2041-1723https://doaj.org/article/dd61e81e8545472a93ddce68c769d81d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04668-whttps://doaj.org/toc/2041-1723Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels.Seyedeh M. ZekavatSanni RuotsalainenRobert E. HandsakerMaris AlverJonathan BloomTimothy PoterbaCotton SeedJason ErnstMark ChaffinJesse EngreitzGina M. PelosoAni ManichaikulChaojie YangKathleen A. RyanMao FuW. Craig JohnsonMichael TsaiMatthew BudoffRamachandran S. VasanL. Adrienne CupplesJerome I. RotterStephen S. RichWendy PostBraxton D. MitchellAdolfo CorreaAndres MetspaluJames G. WilsonVeikko SalomaaManolis KellisMark J. DalyBenjamin M. NealeSteven McCarrollIda SurakkaTonu EskoAndrea GannaSamuli RipattiSekar KathiresanPradeep NatarajanNHLBI TOPMed Lipids Working GroupNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
description	Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels.
format	article
author	Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group
author_facet	Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group
author_sort	Seyedeh M. Zekavat
title	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
title_short	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
title_full	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
title_fullStr	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
title_full_unstemmed	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
title_sort	deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of european and african ancestries
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dd61e81e8545472a93ddce68c769d81d
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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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