The glycome of normal and malignant plasma cells.

The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcrip...

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Autores principales:	Thomas M Moehler, Anja Seckinger, Dirk Hose, Mindaugas Andrulis, Jèrôme Moreaux, Thomas Hielscher, Martina Willhauck-Fleckenstein, Anette Merling, Uta Bertsch, Anna Jauch, Hartmut Goldschmidt, Bernard Klein, Reinhard Schwartz-Albiez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd627b36aef541cdad326231c4f55164
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spelling	oai:doaj.org-article:dd627b36aef541cdad326231c4f551642021-11-18T08:40:19ZThe glycome of normal and malignant plasma cells.1932-620310.1371/journal.pone.0083719https://doaj.org/article/dd627b36aef541cdad326231c4f551642013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386263/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant plasma-cell samples, association with known multiple myeloma subentities as defined by presence of chromosomal aberrations, potential therapeutic targets, and its prognostic impact. We found i) malignant vs. normal plasma cells to show a characteristic glycome-signature. They can ii) be delineated by a lasso-based predictor from normal plasma cells based on this signature. iii) Cytogenetic aberrations lead to distinct glycan-gene expression patterns for t(11;14), t(4;14), hyperdiploidy, 1q21-gain and deletion of 13q14. iv) A 38-gene glycome-signature significantly delineates patients with adverse survival in two independent cohorts of 545 patients treated with high-dose melphalan and autologous stem cell transplantation. v) As single gene, expression of the phosphatidyl-inositol-glycan protein M as part of the targetable glycosyl-phosphatidyl-inositol-anchor-biosynthesis pathway is associated with adverse survival. The prognostically relevant glycome deviation in malignant cells invites novel strategies of therapy for multiple myeloma.Thomas M MoehlerAnja SeckingerDirk HoseMindaugas AndrulisJèrôme MoreauxThomas HielscherMartina Willhauck-FleckensteinAnette MerlingUta BertschAnna JauchHartmut GoldschmidtBernard KleinReinhard Schwartz-AlbiezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83719 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas M Moehler Anja Seckinger Dirk Hose Mindaugas Andrulis Jèrôme Moreaux Thomas Hielscher Martina Willhauck-Fleckenstein Anette Merling Uta Bertsch Anna Jauch Hartmut Goldschmidt Bernard Klein Reinhard Schwartz-Albiez The glycome of normal and malignant plasma cells.
description	The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant plasma-cell samples, association with known multiple myeloma subentities as defined by presence of chromosomal aberrations, potential therapeutic targets, and its prognostic impact. We found i) malignant vs. normal plasma cells to show a characteristic glycome-signature. They can ii) be delineated by a lasso-based predictor from normal plasma cells based on this signature. iii) Cytogenetic aberrations lead to distinct glycan-gene expression patterns for t(11;14), t(4;14), hyperdiploidy, 1q21-gain and deletion of 13q14. iv) A 38-gene glycome-signature significantly delineates patients with adverse survival in two independent cohorts of 545 patients treated with high-dose melphalan and autologous stem cell transplantation. v) As single gene, expression of the phosphatidyl-inositol-glycan protein M as part of the targetable glycosyl-phosphatidyl-inositol-anchor-biosynthesis pathway is associated with adverse survival. The prognostically relevant glycome deviation in malignant cells invites novel strategies of therapy for multiple myeloma.
format	article
author	Thomas M Moehler Anja Seckinger Dirk Hose Mindaugas Andrulis Jèrôme Moreaux Thomas Hielscher Martina Willhauck-Fleckenstein Anette Merling Uta Bertsch Anna Jauch Hartmut Goldschmidt Bernard Klein Reinhard Schwartz-Albiez
author_facet	Thomas M Moehler Anja Seckinger Dirk Hose Mindaugas Andrulis Jèrôme Moreaux Thomas Hielscher Martina Willhauck-Fleckenstein Anette Merling Uta Bertsch Anna Jauch Hartmut Goldschmidt Bernard Klein Reinhard Schwartz-Albiez
author_sort	Thomas M Moehler
title	The glycome of normal and malignant plasma cells.
title_short	The glycome of normal and malignant plasma cells.
title_full	The glycome of normal and malignant plasma cells.
title_fullStr	The glycome of normal and malignant plasma cells.
title_full_unstemmed	The glycome of normal and malignant plasma cells.
title_sort	glycome of normal and malignant plasma cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/dd627b36aef541cdad326231c4f55164
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The glycome of normal and malignant plasma cells.

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