Aging Immune System and Its Correlation With Liability to Severe Lung Complications

Aging is considered to be a decline in physical and physiological events that extensively affect the body's immunity, and is linked with deterioration in both innate and adaptive immune responses. The immune system exhibits profound age-associated variations, known as immunosenescence, comprisi...

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Autores principales:	Yongtao Li, Chengfei Wang, Meilian Peng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging immunity immunosenescence mortality lung complications lymphocytes Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/dd660b7644c3497f968fc01c59905b7a
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spelling	oai:doaj.org-article:dd660b7644c3497f968fc01c59905b7a2021-11-30T14:01:57ZAging Immune System and Its Correlation With Liability to Severe Lung Complications2296-256510.3389/fpubh.2021.735151https://doaj.org/article/dd660b7644c3497f968fc01c59905b7a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.735151/fullhttps://doaj.org/toc/2296-2565Aging is considered to be a decline in physical and physiological events that extensively affect the body's immunity, and is linked with deterioration in both innate and adaptive immune responses. The immune system exhibits profound age-associated variations, known as immunosenescence, comprising a significantly low production of B and T lymphocytes in bone marrow and thymus, a decreased function of mature lymphocytes in secondary lymphoid tissues, a decrease in the synthesis of fresh naïve T cells, and reduced activation of T cells. Elderly individuals face a greater risk for many diseases particularly respiratory diseases due to their poor response to immune challenges as vigorously as the young. The current review explored the aging immune system, highlight the mortality rates of severe lung complications, such as pneumonia, COVID-19, asthma, COPD, lung cancer, IPF, and acute lung injury, and their correlation with aging immunity. This study can be helpful in better understanding the pathophysiology of aging, immune responses, and developing new approaches to improve the average age of the elderly population.Yongtao LiChengfei WangMeilian PengFrontiers Media S.A.articleaging immunityimmunosenescencemortalitylung complicationslymphocytesPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging immunity immunosenescence mortality lung complications lymphocytes Public aspects of medicine RA1-1270
spellingShingle	aging immunity immunosenescence mortality lung complications lymphocytes Public aspects of medicine RA1-1270 Yongtao Li Chengfei Wang Meilian Peng Aging Immune System and Its Correlation With Liability to Severe Lung Complications
description	Aging is considered to be a decline in physical and physiological events that extensively affect the body's immunity, and is linked with deterioration in both innate and adaptive immune responses. The immune system exhibits profound age-associated variations, known as immunosenescence, comprising a significantly low production of B and T lymphocytes in bone marrow and thymus, a decreased function of mature lymphocytes in secondary lymphoid tissues, a decrease in the synthesis of fresh naïve T cells, and reduced activation of T cells. Elderly individuals face a greater risk for many diseases particularly respiratory diseases due to their poor response to immune challenges as vigorously as the young. The current review explored the aging immune system, highlight the mortality rates of severe lung complications, such as pneumonia, COVID-19, asthma, COPD, lung cancer, IPF, and acute lung injury, and their correlation with aging immunity. This study can be helpful in better understanding the pathophysiology of aging, immune responses, and developing new approaches to improve the average age of the elderly population.
format	article
author	Yongtao Li Chengfei Wang Meilian Peng
author_facet	Yongtao Li Chengfei Wang Meilian Peng
author_sort	Yongtao Li
title	Aging Immune System and Its Correlation With Liability to Severe Lung Complications
title_short	Aging Immune System and Its Correlation With Liability to Severe Lung Complications
title_full	Aging Immune System and Its Correlation With Liability to Severe Lung Complications
title_fullStr	Aging Immune System and Its Correlation With Liability to Severe Lung Complications
title_full_unstemmed	Aging Immune System and Its Correlation With Liability to Severe Lung Complications
title_sort	aging immune system and its correlation with liability to severe lung complications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dd660b7644c3497f968fc01c59905b7a
work_keys_str_mv	AT yongtaoli agingimmunesystemanditscorrelationwithliabilitytoseverelungcomplications AT chengfeiwang agingimmunesystemanditscorrelationwithliabilitytoseverelungcomplications AT meilianpeng agingimmunesystemanditscorrelationwithliabilitytoseverelungcomplications
_version_	1718406534887636992

Aging Immune System and Its Correlation With Liability to Severe Lung Complications

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