The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.

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Autores principales: Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dd6a306bbe1846f28cbf4f152c659197
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spelling oai:doaj.org-article:dd6a306bbe1846f28cbf4f152c6591972021-12-02T14:23:03ZThe SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA10.1038/s41467-021-21953-32041-1723https://doaj.org/article/dd6a306bbe1846f28cbf4f152c6591972021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21953-3https://doaj.org/toc/2041-1723SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.Jasmine CubukJhullian J. AlstonJ. Jeremías InciccoSukrit SinghMelissa D. Stuchell-BreretonMichael D. WardMaxwell I. ZimmermanNeha VithaniDaniel GriffithJason A. WagonerGregory R. BowmanKathleen B. HallAndrea SorannoAlex S. HolehouseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jasmine Cubuk
Jhullian J. Alston
J. Jeremías Incicco
Sukrit Singh
Melissa D. Stuchell-Brereton
Michael D. Ward
Maxwell I. Zimmerman
Neha Vithani
Daniel Griffith
Jason A. Wagoner
Gregory R. Bowman
Kathleen B. Hall
Andrea Soranno
Alex S. Holehouse
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
description SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.
format article
author Jasmine Cubuk
Jhullian J. Alston
J. Jeremías Incicco
Sukrit Singh
Melissa D. Stuchell-Brereton
Michael D. Ward
Maxwell I. Zimmerman
Neha Vithani
Daniel Griffith
Jason A. Wagoner
Gregory R. Bowman
Kathleen B. Hall
Andrea Soranno
Alex S. Holehouse
author_facet Jasmine Cubuk
Jhullian J. Alston
J. Jeremías Incicco
Sukrit Singh
Melissa D. Stuchell-Brereton
Michael D. Ward
Maxwell I. Zimmerman
Neha Vithani
Daniel Griffith
Jason A. Wagoner
Gregory R. Bowman
Kathleen B. Hall
Andrea Soranno
Alex S. Holehouse
author_sort Jasmine Cubuk
title The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
title_short The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
title_full The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
title_fullStr The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
title_full_unstemmed The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
title_sort sars-cov-2 nucleocapsid protein is dynamic, disordered, and phase separates with rna
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/dd6a306bbe1846f28cbf4f152c659197
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