The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.
Guardado en:
Autores principales: | Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/dd6a306bbe1846f28cbf4f152c659197 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A multi-step nucleation process determines the kinetics of prion-like domain phase separation
por: Erik W. Martin, et al.
Publicado: (2021) -
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
por: Adriana Savastano, et al.
Publicado: (2020) -
The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation
por: Sébastien Lyonnais, et al.
Publicado: (2021) -
PARROT is a flexible recurrent neural network framework for analysis of large protein datasets
por: Daniel Griffith, et al.
Publicado: (2021) -
Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly
por: Judy J. Wan, et al.
Publicado: (2020)