A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
Necroptotic cells activate MLKL and release inflammatory DAMPs, although the underlying regulatory mechanisms of this process are poorly understood. Here, Murai et al. develop a necroptosis-specific FRET sensor (SMART) that monitors MLKL membrane translocation to identify two modes of DAMP release.
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Nature Portfolio
2018
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oai:doaj.org-article:dd6ff8d68eec4a60838196219a4980cf2021-12-02T17:31:46ZA FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs10.1038/s41467-018-06985-62041-1723https://doaj.org/article/dd6ff8d68eec4a60838196219a4980cf2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06985-6https://doaj.org/toc/2041-1723Necroptotic cells activate MLKL and release inflammatory DAMPs, although the underlying regulatory mechanisms of this process are poorly understood. Here, Murai et al. develop a necroptosis-specific FRET sensor (SMART) that monitors MLKL membrane translocation to identify two modes of DAMP release.Shin MuraiYoshifumi YamaguchiYoshitaka ShirasakiMai YamagishiRyodai ShindoJoanne M. HildebrandRyosuke MiuraOsamu NakabayashiMamoru TotsukaTaichiro TomidaSatomi Adachi-AkahaneSotaro UemuraJohn SilkeHideo YagitaMasayuki MiuraHiroyasu NakanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shin Murai Yoshifumi Yamaguchi Yoshitaka Shirasaki Mai Yamagishi Ryodai Shindo Joanne M. Hildebrand Ryosuke Miura Osamu Nakabayashi Mamoru Totsuka Taichiro Tomida Satomi Adachi-Akahane Sotaro Uemura John Silke Hideo Yagita Masayuki Miura Hiroyasu Nakano A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| description |
Necroptotic cells activate MLKL and release inflammatory DAMPs, although the underlying regulatory mechanisms of this process are poorly understood. Here, Murai et al. develop a necroptosis-specific FRET sensor (SMART) that monitors MLKL membrane translocation to identify two modes of DAMP release. |
| format |
article |
| author |
Shin Murai Yoshifumi Yamaguchi Yoshitaka Shirasaki Mai Yamagishi Ryodai Shindo Joanne M. Hildebrand Ryosuke Miura Osamu Nakabayashi Mamoru Totsuka Taichiro Tomida Satomi Adachi-Akahane Sotaro Uemura John Silke Hideo Yagita Masayuki Miura Hiroyasu Nakano |
| author_facet |
Shin Murai Yoshifumi Yamaguchi Yoshitaka Shirasaki Mai Yamagishi Ryodai Shindo Joanne M. Hildebrand Ryosuke Miura Osamu Nakabayashi Mamoru Totsuka Taichiro Tomida Satomi Adachi-Akahane Sotaro Uemura John Silke Hideo Yagita Masayuki Miura Hiroyasu Nakano |
| author_sort |
Shin Murai |
| title |
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| title_short |
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| title_full |
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| title_fullStr |
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| title_full_unstemmed |
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs |
| title_sort |
fret biosensor for necroptosis uncovers two different modes of the release of damps |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/dd6ff8d68eec4a60838196219a4980cf |
| work_keys_str_mv |
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