Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.

Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imag...

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Autores principales:	Ulrike Kuhl, Sarah Sobotta, Legascreen Consortium, Michael A Skeide
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dd71ba5f9b964a8a9ab500239eb09d8c
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spelling	oai:doaj.org-article:dd71ba5f9b964a8a9ab500239eb09d8c2021-12-02T19:54:34ZMathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.1544-91731545-788510.1371/journal.pbio.3001407https://doaj.org/article/dd71ba5f9b964a8a9ab500239eb09d8c2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001407https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imaging (MRI) experiments in 3- to 6-year-old children without formal mathematical learning experience. We followed this sample until the age of 7 to 9 years, identified individuals who developed deficits, and matched them to a typically developing control group using comprehensive behavioral assessments. Multivariate pattern classification distinguished future cases from controls with up to 87% accuracy based on the regional functional activity of the right posterior parietal cortex (PPC), the network-level functional activity of the right dorsolateral prefrontal cortex (DLPFC), and the effective functional and structural connectivity of these regions. Our results indicate that mathematical learning deficits originate from atypical development of a frontoparietal network that is already detectable in early childhood.Ulrike KuhlSarah SobottaLegascreen ConsortiumMichael A SkeidePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001407 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ulrike Kuhl Sarah Sobotta Legascreen Consortium Michael A Skeide Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
description	Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imaging (MRI) experiments in 3- to 6-year-old children without formal mathematical learning experience. We followed this sample until the age of 7 to 9 years, identified individuals who developed deficits, and matched them to a typically developing control group using comprehensive behavioral assessments. Multivariate pattern classification distinguished future cases from controls with up to 87% accuracy based on the regional functional activity of the right posterior parietal cortex (PPC), the network-level functional activity of the right dorsolateral prefrontal cortex (DLPFC), and the effective functional and structural connectivity of these regions. Our results indicate that mathematical learning deficits originate from atypical development of a frontoparietal network that is already detectable in early childhood.
format	article
author	Ulrike Kuhl Sarah Sobotta Legascreen Consortium Michael A Skeide
author_facet	Ulrike Kuhl Sarah Sobotta Legascreen Consortium Michael A Skeide
author_sort	Ulrike Kuhl
title	Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
title_short	Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
title_full	Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
title_fullStr	Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
title_full_unstemmed	Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
title_sort	mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd71ba5f9b964a8a9ab500239eb09d8c
work_keys_str_mv	AT ulrikekuhl mathematicallearningdeficitsoriginateinearlychildhoodfromatypicaldevelopmentofafrontoparietalbrainnetwork AT sarahsobotta mathematicallearningdeficitsoriginateinearlychildhoodfromatypicaldevelopmentofafrontoparietalbrainnetwork AT legascreenconsortium mathematicallearningdeficitsoriginateinearlychildhoodfromatypicaldevelopmentofafrontoparietalbrainnetwork AT michaelaskeide mathematicallearningdeficitsoriginateinearlychildhoodfromatypicaldevelopmentofafrontoparietalbrainnetwork
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Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.

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