Morphological changes in liver of methimazole treated rats, a pilot study
BACKGROUND & OBJECTIVE: Thyrotoxicosis is a disease in which thyroid hormones are raised, and we have seen multiple patients suffering from this ailment in Pakistan. Methimazole is an anti-thyroid drug for thyrotoxicosis. Hepatotoxicity and liver ailments were common with methimazole prescribed...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
University of Faisalabad
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/dd723423898245ff9c13bc0123de76fb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | BACKGROUND & OBJECTIVE: Thyrotoxicosis is a disease in which thyroid hormones are raised, and we have seen multiple patients suffering from this ailment in Pakistan. Methimazole is an anti-thyroid drug for thyrotoxicosis. Hepatotoxicity and liver ailments were common with methimazole prescribed for hypothyroid patients. Hypothyroidism, a common side effect of this drug, has been seen in a majority of patients, but liver toxicity remained unaddressed. So, in this study, we have observed histological changes in the liver after methimazole administration.
METHODOLOGY: The pilot study was carried out in the University of Health Sciences (UHS), Lahore, and was ended in twenty-one days. We divided animals in 2 groups. Each group comprises 12 animals. Group-I was negative control, and water was given through the oral route for 21 days. Group-II was administered methimazole orally 60mg/kg/day for twenty-one days. At the end;S animals were dissected, and livers were removed for histological examination.
RESULTS: The histological picture of the liver showed 75% severe disruption in liver architecture, inflammation, and fatty change in group 2, indicating liver damage.
CONCLUSION: Methimazole, hepatotoxic with discernable damage to its architecture, epithelium, and inflammatory changes.
|
|---|