Morphological changes in liver of methimazole treated rats, a pilot study

BACKGROUND & OBJECTIVE: Thyrotoxicosis is a disease in which thyroid hormones are raised, and we have seen multiple patients suffering from this ailment in Pakistan. Methimazole is an anti-thyroid drug for thyrotoxicosis. Hepatotoxicity and liver ailments were common with methimazole prescribed...

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Autores principales:	Maira Bhatti, Waqas Iqbal Butt, Shahnaz Fatima, Fouzia Perveen, Sabeen Arjumand, Amna Iqbal Butt
Formato:	article
Lenguaje:	EN
Publicado:	University of Faisalabad 2021
Materias:	Methimazole Thyroxine and liver Medicine R
Acceso en línea:	https://doaj.org/article/dd723423898245ff9c13bc0123de76fb
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spelling	oai:doaj.org-article:dd723423898245ff9c13bc0123de76fb2021-11-28T06:14:56ZMorphological changes in liver of methimazole treated rats, a pilot study10.37723/jumdc.v12i4.5372221-78272310-5542https://doaj.org/article/dd723423898245ff9c13bc0123de76fb2021-10-01T00:00:00Zhttp://www.jumdc.com/index.php/jumdc/article/view/537https://doaj.org/toc/2221-7827https://doaj.org/toc/2310-5542 BACKGROUND & OBJECTIVE: Thyrotoxicosis is a disease in which thyroid hormones are raised, and we have seen multiple patients suffering from this ailment in Pakistan. Methimazole is an anti-thyroid drug for thyrotoxicosis. Hepatotoxicity and liver ailments were common with methimazole prescribed for hypothyroid patients. Hypothyroidism, a common side effect of this drug, has been seen in a majority of patients, but liver toxicity remained unaddressed. So, in this study, we have observed histological changes in the liver after methimazole administration. METHODOLOGY: The pilot study was carried out in the University of Health Sciences (UHS), Lahore, and was ended in twenty-one days. We divided animals in 2 groups. Each group comprises 12 animals. Group-I was negative control, and water was given through the oral route for 21 days. Group-II was administered methimazole orally 60mg/kg/day for twenty-one days. At the end;S animals were dissected, and livers were removed for histological examination. RESULTS: The histological picture of the liver showed 75% severe disruption in liver architecture, inflammation, and fatty change in group 2, indicating liver damage. CONCLUSION: Methimazole, hepatotoxic with discernable damage to its architecture, epithelium, and inflammatory changes. Maira BhattiWaqas Iqbal ButtShahnaz FatimaFouzia PerveenSabeen ArjumandAmna Iqbal ButtUniversity of FaisalabadarticleMethimazoleThyroxineand liverMedicineRENJournal of University Medical & Dental College, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Methimazole Thyroxine and liver Medicine R
spellingShingle	Methimazole Thyroxine and liver Medicine R Maira Bhatti Waqas Iqbal Butt Shahnaz Fatima Fouzia Perveen Sabeen Arjumand Amna Iqbal Butt Morphological changes in liver of methimazole treated rats, a pilot study
description	BACKGROUND & OBJECTIVE: Thyrotoxicosis is a disease in which thyroid hormones are raised, and we have seen multiple patients suffering from this ailment in Pakistan. Methimazole is an anti-thyroid drug for thyrotoxicosis. Hepatotoxicity and liver ailments were common with methimazole prescribed for hypothyroid patients. Hypothyroidism, a common side effect of this drug, has been seen in a majority of patients, but liver toxicity remained unaddressed. So, in this study, we have observed histological changes in the liver after methimazole administration. METHODOLOGY: The pilot study was carried out in the University of Health Sciences (UHS), Lahore, and was ended in twenty-one days. We divided animals in 2 groups. Each group comprises 12 animals. Group-I was negative control, and water was given through the oral route for 21 days. Group-II was administered methimazole orally 60mg/kg/day for twenty-one days. At the end;S animals were dissected, and livers were removed for histological examination. RESULTS: The histological picture of the liver showed 75% severe disruption in liver architecture, inflammation, and fatty change in group 2, indicating liver damage. CONCLUSION: Methimazole, hepatotoxic with discernable damage to its architecture, epithelium, and inflammatory changes.
format	article
author	Maira Bhatti Waqas Iqbal Butt Shahnaz Fatima Fouzia Perveen Sabeen Arjumand Amna Iqbal Butt
author_facet	Maira Bhatti Waqas Iqbal Butt Shahnaz Fatima Fouzia Perveen Sabeen Arjumand Amna Iqbal Butt
author_sort	Maira Bhatti
title	Morphological changes in liver of methimazole treated rats, a pilot study
title_short	Morphological changes in liver of methimazole treated rats, a pilot study
title_full	Morphological changes in liver of methimazole treated rats, a pilot study
title_fullStr	Morphological changes in liver of methimazole treated rats, a pilot study
title_full_unstemmed	Morphological changes in liver of methimazole treated rats, a pilot study
title_sort	morphological changes in liver of methimazole treated rats, a pilot study
publisher	University of Faisalabad
publishDate	2021
url	https://doaj.org/article/dd723423898245ff9c13bc0123de76fb
work_keys_str_mv	AT mairabhatti morphologicalchangesinliverofmethimazoletreatedratsapilotstudy AT waqasiqbalbutt morphologicalchangesinliverofmethimazoletreatedratsapilotstudy AT shahnazfatima morphologicalchangesinliverofmethimazoletreatedratsapilotstudy AT fouziaperveen morphologicalchangesinliverofmethimazoletreatedratsapilotstudy AT sabeenarjumand morphologicalchangesinliverofmethimazoletreatedratsapilotstudy AT amnaiqbalbutt morphologicalchangesinliverofmethimazoletreatedratsapilotstudy
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Morphological changes in liver of methimazole treated rats, a pilot study

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