Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

In the differential diagnosis of nonspecific white matter lesions (NSWMLs) detected on magnetic resonance imaging (MRI), multiple sclerosis (MS) should be taken into consideration. Optical coherence tomography (OCT) is a promising tool applied in the differential diagnostic process of MS. We tested...

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Autores principales:	Małgorzata Siger, Marta Owidzka, Mariola Świderek-Matysiak, Wojciech Omulecki, Mariusz Stasiołek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple sclerosis nonspecific white matter lesions differential diagnosis optical coherence tomography Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/dd7264f2edba4606a9bf0f2c84374318
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spelling	oai:doaj.org-article:dd7264f2edba4606a9bf0f2c843743182021-11-11T19:07:46ZOptical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions10.3390/s212171271424-8220https://doaj.org/article/dd7264f2edba4606a9bf0f2c843743182021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/21/7127https://doaj.org/toc/1424-8220In the differential diagnosis of nonspecific white matter lesions (NSWMLs) detected on magnetic resonance imaging (MRI), multiple sclerosis (MS) should be taken into consideration. Optical coherence tomography (OCT) is a promising tool applied in the differential diagnostic process of MS. We tested whether OCT may be useful in distinguishing between MS and NSWMLs patients. In patients with MS (n = 41) and NSWMLs (n = 19), the following OCT parameters were measured: thickness of the peripapillary Retinal Nerve Fibre Layer (pRNFL) in superior, inferior, nasal, and temporal segments; thickness of the ganglion cell-inner plexiform layer (GCIPL); thickness of macular RNFL (mRNFL); and macular volume (MV). In MS patients, GCIPL was significantly lower than in NSWMLs patients (<i>p</i> = 0.024). Additionally, in MS patients, mRNFL was significantly lower than in NSWMLs patients (<i>p</i> = 0.030). The average segmental pRNFL and MV did not differ between MS and NSWMLs patients (<i>p</i> > 0.05). GCIPL and macular RNFL thinning significantly influenced the risk of MS (18.6% [95% CI 2.7%, 25.3%]; 27.4% [95% CI 4.5%, 62.3%]), and reduced GCIPL thickness appeared to be the best predictor of MS. We conclude that OCT may be helpful in the differential diagnosis of MS and NSWMLs patients in real-world settings.Małgorzata SigerMarta OwidzkaMariola Świderek-MatysiakWojciech OmuleckiMariusz StasiołekMDPI AGarticlemultiple sclerosisnonspecific white matter lesionsdifferential diagnosisoptical coherence tomographyChemical technologyTP1-1185ENSensors, Vol 21, Iss 7127, p 7127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis nonspecific white matter lesions differential diagnosis optical coherence tomography Chemical technology TP1-1185
spellingShingle	multiple sclerosis nonspecific white matter lesions differential diagnosis optical coherence tomography Chemical technology TP1-1185 Małgorzata Siger Marta Owidzka Mariola Świderek-Matysiak Wojciech Omulecki Mariusz Stasiołek Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
description	In the differential diagnosis of nonspecific white matter lesions (NSWMLs) detected on magnetic resonance imaging (MRI), multiple sclerosis (MS) should be taken into consideration. Optical coherence tomography (OCT) is a promising tool applied in the differential diagnostic process of MS. We tested whether OCT may be useful in distinguishing between MS and NSWMLs patients. In patients with MS (n = 41) and NSWMLs (n = 19), the following OCT parameters were measured: thickness of the peripapillary Retinal Nerve Fibre Layer (pRNFL) in superior, inferior, nasal, and temporal segments; thickness of the ganglion cell-inner plexiform layer (GCIPL); thickness of macular RNFL (mRNFL); and macular volume (MV). In MS patients, GCIPL was significantly lower than in NSWMLs patients (<i>p</i> = 0.024). Additionally, in MS patients, mRNFL was significantly lower than in NSWMLs patients (<i>p</i> = 0.030). The average segmental pRNFL and MV did not differ between MS and NSWMLs patients (<i>p</i> > 0.05). GCIPL and macular RNFL thinning significantly influenced the risk of MS (18.6% [95% CI 2.7%, 25.3%]; 27.4% [95% CI 4.5%, 62.3%]), and reduced GCIPL thickness appeared to be the best predictor of MS. We conclude that OCT may be helpful in the differential diagnosis of MS and NSWMLs patients in real-world settings.
format	article
author	Małgorzata Siger Marta Owidzka Mariola Świderek-Matysiak Wojciech Omulecki Mariusz Stasiołek
author_facet	Małgorzata Siger Marta Owidzka Mariola Świderek-Matysiak Wojciech Omulecki Mariusz Stasiołek
author_sort	Małgorzata Siger
title	Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
title_short	Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
title_full	Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
title_fullStr	Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
title_full_unstemmed	Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions
title_sort	optical coherence tomography in the differential diagnosis of patients with multiple sclerosis and patients with mri nonspecific white matter lesions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dd7264f2edba4606a9bf0f2c84374318
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Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

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