Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin

A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligan...

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Autores principales:	Sanliang Li, Qiaoyu Chen, Zhan-Ming Zhang, Junliang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co. Ltd. 2021
Materias:	Palladium Alkenes Asymmetric catalysis Quaternary stereocenter Dihydroisoquinolinone Chemical technology TP1-1185 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/dd732803d4564fb7916cd1148cefcfa4
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spelling	oai:doaj.org-article:dd732803d4564fb7916cd1148cefcfa42021-12-02T05:03:58ZPd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin2666-554910.1016/j.gresc.2021.10.006https://doaj.org/article/dd732803d4564fb7916cd1148cefcfa42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666554921000879https://doaj.org/toc/2666-5549A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligand and diverse transformations.Sanliang LiQiaoyu ChenZhan-Ming ZhangJunliang ZhangKeAi Communications Co. Ltd.articlePalladiumAlkenesAsymmetric catalysisQuaternary stereocenterDihydroisoquinolinoneChemical technologyTP1-1185BiochemistryQD415-436ENGreen Synthesis and Catalysis, Vol 2, Iss 4, Pp 374-376 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Palladium Alkenes Asymmetric catalysis Quaternary stereocenter Dihydroisoquinolinone Chemical technology TP1-1185 Biochemistry QD415-436
spellingShingle	Palladium Alkenes Asymmetric catalysis Quaternary stereocenter Dihydroisoquinolinone Chemical technology TP1-1185 Biochemistry QD415-436 Sanliang Li Qiaoyu Chen Zhan-Ming Zhang Junliang Zhang Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
description	A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligand and diverse transformations.
format	article
author	Sanliang Li Qiaoyu Chen Zhan-Ming Zhang Junliang Zhang
author_facet	Sanliang Li Qiaoyu Chen Zhan-Ming Zhang Junliang Zhang
author_sort	Sanliang Li
title	Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
title_short	Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
title_full	Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
title_fullStr	Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
title_full_unstemmed	Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
title_sort	pd-catalyzed enantioselective intramolecular heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
publisher	KeAi Communications Co. Ltd.
publishDate	2021
url	https://doaj.org/article/dd732803d4564fb7916cd1148cefcfa4
work_keys_str_mv	AT sanliangli pdcatalyzedenantioselectiveintramolecularheckreactiontoaccessdisubstituteddihydroisoquinolinonewithaterminalolefin AT qiaoyuchen pdcatalyzedenantioselectiveintramolecularheckreactiontoaccessdisubstituteddihydroisoquinolinonewithaterminalolefin AT zhanmingzhang pdcatalyzedenantioselectiveintramolecularheckreactiontoaccessdisubstituteddihydroisoquinolinonewithaterminalolefin AT junliangzhang pdcatalyzedenantioselectiveintramolecularheckreactiontoaccessdisubstituteddihydroisoquinolinonewithaterminalolefin
_version_	1718400681908371456

Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin

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