Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.

Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying sperm migration are mostly unknown, since in vivo investigations are mostly un...

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Autores principales:	Jorin Diemer, Jens Hahn, Björn Goldenbogen, Karin Müller, Edda Klipp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dd7bc172997747fa906c8bbc7219e89b
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spelling	oai:doaj.org-article:dd7bc172997747fa906c8bbc7219e89b2021-12-02T19:57:32ZSperm migration in the genital tract-In silico experiments identify key factors for reproductive success.1553-734X1553-735810.1371/journal.pcbi.1009109https://doaj.org/article/dd7bc172997747fa906c8bbc7219e89b2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009109https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying sperm migration are mostly unknown, since in vivo investigations are mostly unfeasible for ethical or practical reasons. By presenting a spatio-temporal model of the mammalian female genital tract combined with agent-based description of sperm motion and interaction as well as parameterizing it with bovine data, we offer an alternative possibility for studying sperm migration in silico. The model incorporates genital tract geometry as well as biophysical principles of sperm motion observed in vitro such as positive rheotaxis and thigmotaxis. This model for sperm migration from vagina to oviducts was successfully tested against in vivo data from literature. We found that physical sperm characteristics such as velocity and directional stability as well as sperm-fluid interactions and wall alignment are critical for success, i.e. sperms reaching the oviducts. Therefore, we propose that these identified sperm parameters should be considered in detail for conditioning sperm in artificial selection procedures since the natural processes are normally bypassed in reproductive in vitro technologies. The tremendous impact of mucus flow to support sperm accumulation in the oviduct highlights the importance of a species-specific optimum time window for artificial insemination regarding ovulation. Predictions from our extendable in silico experimental system will improve assisted reproduction in humans, endangered species, and livestock.Jorin DiemerJens HahnBjörn GoldenbogenKarin MüllerEdda KlippPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009109 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jorin Diemer Jens Hahn Björn Goldenbogen Karin Müller Edda Klipp Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
description	Sperm migration in the female genital tract controls sperm selection and, therefore, reproductive success as male gametes are conditioned for fertilization while their number is dramatically reduced. Mechanisms underlying sperm migration are mostly unknown, since in vivo investigations are mostly unfeasible for ethical or practical reasons. By presenting a spatio-temporal model of the mammalian female genital tract combined with agent-based description of sperm motion and interaction as well as parameterizing it with bovine data, we offer an alternative possibility for studying sperm migration in silico. The model incorporates genital tract geometry as well as biophysical principles of sperm motion observed in vitro such as positive rheotaxis and thigmotaxis. This model for sperm migration from vagina to oviducts was successfully tested against in vivo data from literature. We found that physical sperm characteristics such as velocity and directional stability as well as sperm-fluid interactions and wall alignment are critical for success, i.e. sperms reaching the oviducts. Therefore, we propose that these identified sperm parameters should be considered in detail for conditioning sperm in artificial selection procedures since the natural processes are normally bypassed in reproductive in vitro technologies. The tremendous impact of mucus flow to support sperm accumulation in the oviduct highlights the importance of a species-specific optimum time window for artificial insemination regarding ovulation. Predictions from our extendable in silico experimental system will improve assisted reproduction in humans, endangered species, and livestock.
format	article
author	Jorin Diemer Jens Hahn Björn Goldenbogen Karin Müller Edda Klipp
author_facet	Jorin Diemer Jens Hahn Björn Goldenbogen Karin Müller Edda Klipp
author_sort	Jorin Diemer
title	Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
title_short	Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
title_full	Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
title_fullStr	Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
title_full_unstemmed	Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.
title_sort	sperm migration in the genital tract-in silico experiments identify key factors for reproductive success.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd7bc172997747fa906c8bbc7219e89b
work_keys_str_mv	AT jorindiemer spermmigrationinthegenitaltractinsilicoexperimentsidentifykeyfactorsforreproductivesuccess AT jenshahn spermmigrationinthegenitaltractinsilicoexperimentsidentifykeyfactorsforreproductivesuccess AT bjorngoldenbogen spermmigrationinthegenitaltractinsilicoexperimentsidentifykeyfactorsforreproductivesuccess AT karinmuller spermmigrationinthegenitaltractinsilicoexperimentsidentifykeyfactorsforreproductivesuccess AT eddaklipp spermmigrationinthegenitaltractinsilicoexperimentsidentifykeyfactorsforreproductivesuccess
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Sperm migration in the genital tract-In silico experiments identify key factors for reproductive success.

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