Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.

Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Tech...

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Autores principales:	Stéphane Urcun, Pierre-Yves Rohan, Wafa Skalli, Pierre Nassoy, Stéphane P A Bordas, Giuseppe Sciumè
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd81594c59a14be5a265d7b7b99e8402
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spelling	oai:doaj.org-article:dd81594c59a14be5a265d7b7b99e84022021-12-02T20:15:27ZDigital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.1932-620310.1371/journal.pone.0254512https://doaj.org/article/dd81594c59a14be5a265d7b7b99e84022021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254512https://doaj.org/toc/1932-6203Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play. Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.Stéphane UrcunPierre-Yves RohanWafa SkalliPierre NassoyStéphane P A BordasGiuseppe SciumèPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254512 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stéphane Urcun Pierre-Yves Rohan Wafa Skalli Pierre Nassoy Stéphane P A Bordas Giuseppe Sciumè Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
description	Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play. Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.
format	article
author	Stéphane Urcun Pierre-Yves Rohan Wafa Skalli Pierre Nassoy Stéphane P A Bordas Giuseppe Sciumè
author_facet	Stéphane Urcun Pierre-Yves Rohan Wafa Skalli Pierre Nassoy Stéphane P A Bordas Giuseppe Sciumè
author_sort	Stéphane Urcun
title	Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
title_short	Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
title_full	Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
title_fullStr	Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
title_full_unstemmed	Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.
title_sort	digital twinning of cellular capsule technology: emerging outcomes from the perspective of porous media mechanics.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd81594c59a14be5a265d7b7b99e8402
work_keys_str_mv	AT stephaneurcun digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics AT pierreyvesrohan digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics AT wafaskalli digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics AT pierrenassoy digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics AT stephanepabordas digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics AT giuseppesciume digitaltwinningofcellularcapsuletechnologyemergingoutcomesfromtheperspectiveofporousmediamechanics
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Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.

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