Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women

Intrauterine modifiable maternal metabolic factors are essential to the early growth of offspring. The study sought to evaluate the associations of pre-pregnancy BMI and third-trimester fasting plasma glucose (FPG) with offspring growth outcomes within 24 months among GDM-negative pregnant women. Fo...

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Autores principales:	Jiaojiao Zou, Yanting Yang, Qian Wei, Yunhui Zhang, Huijing Shi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pre-pregnancy BMI third-trimester glycemia early life growth GDM-negative pregnant women Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/dd821bb116724a18b8e857448cc65e93
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spelling	oai:doaj.org-article:dd821bb116724a18b8e857448cc65e932021-11-25T18:35:42ZLongitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women10.3390/nu131139712072-6643https://doaj.org/article/dd821bb116724a18b8e857448cc65e932021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3971https://doaj.org/toc/2072-6643Intrauterine modifiable maternal metabolic factors are essential to the early growth of offspring. The study sought to evaluate the associations of pre-pregnancy BMI and third-trimester fasting plasma glucose (FPG) with offspring growth outcomes within 24 months among GDM-negative pregnant women. Four hundred eighty-three mother –offspring dyads were included from the Shanghai Maternal-Child Pairs Cohort. The pregnant women were categorized into four mutually exclusive groups according to pre-pregnancy BMI as normal or overweight/obesity and third-trimester FPG as controlled or not controlled. Offspring growth in early life was indicated by the BAZ (BMI Z-score), catch-up growth, and overweight/obesity. Among those with controlled third-trimester FPG, pre-pregnancy overweight/obesity significantly increased offspring birth weight, BAZ, and risks of overweight/obesity (RR 1.83, 95% CI 1.23 to 2.73) within 24 months. Those who had uncontrolled third-trimester FPG had a reduced risk of offspring overweight/obesity within 24 months by 47%. The combination of pre-pregnancy overweight/obesity and maternal uncontrolled third-trimester FPG increased 5.24-fold risk of offspring catch-up growth within 24 months (<i>p</i> < 0.05). Maternal pre-pregnancy overweight/obesity and uncontrolled third-trimester glycemia among GDM-negative women both have adverse effects on offspring growth within 24 months. With the combination of increasing pre-pregnancy BMI and maternal third-trimester FPG, the possibility of offspring catch-up growth increases.Jiaojiao ZouYanting YangQian WeiYunhui ZhangHuijing ShiMDPI AGarticlepre-pregnancy BMIthird-trimester glycemiaearly life growthGDM-negative pregnant womenNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3971, p 3971 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pre-pregnancy BMI third-trimester glycemia early life growth GDM-negative pregnant women Nutrition. Foods and food supply TX341-641
spellingShingle	pre-pregnancy BMI third-trimester glycemia early life growth GDM-negative pregnant women Nutrition. Foods and food supply TX341-641 Jiaojiao Zou Yanting Yang Qian Wei Yunhui Zhang Huijing Shi Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
description	Intrauterine modifiable maternal metabolic factors are essential to the early growth of offspring. The study sought to evaluate the associations of pre-pregnancy BMI and third-trimester fasting plasma glucose (FPG) with offspring growth outcomes within 24 months among GDM-negative pregnant women. Four hundred eighty-three mother –offspring dyads were included from the Shanghai Maternal-Child Pairs Cohort. The pregnant women were categorized into four mutually exclusive groups according to pre-pregnancy BMI as normal or overweight/obesity and third-trimester FPG as controlled or not controlled. Offspring growth in early life was indicated by the BAZ (BMI Z-score), catch-up growth, and overweight/obesity. Among those with controlled third-trimester FPG, pre-pregnancy overweight/obesity significantly increased offspring birth weight, BAZ, and risks of overweight/obesity (RR 1.83, 95% CI 1.23 to 2.73) within 24 months. Those who had uncontrolled third-trimester FPG had a reduced risk of offspring overweight/obesity within 24 months by 47%. The combination of pre-pregnancy overweight/obesity and maternal uncontrolled third-trimester FPG increased 5.24-fold risk of offspring catch-up growth within 24 months (<i>p</i> < 0.05). Maternal pre-pregnancy overweight/obesity and uncontrolled third-trimester glycemia among GDM-negative women both have adverse effects on offspring growth within 24 months. With the combination of increasing pre-pregnancy BMI and maternal third-trimester FPG, the possibility of offspring catch-up growth increases.
format	article
author	Jiaojiao Zou Yanting Yang Qian Wei Yunhui Zhang Huijing Shi
author_facet	Jiaojiao Zou Yanting Yang Qian Wei Yunhui Zhang Huijing Shi
author_sort	Jiaojiao Zou
title	Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
title_short	Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
title_full	Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
title_fullStr	Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
title_full_unstemmed	Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women
title_sort	longitudinal association of maternal pre-pregnancy bmi and third-trimester glycemia with early life growth of offspring: a prospective study among gdm-negative pregnant women
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dd821bb116724a18b8e857448cc65e93
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Longitudinal Association of Maternal Pre-Pregnancy BMI and Third-Trimester Glycemia with Early Life Growth of Offspring: A Prospective Study among GDM-Negative Pregnant Women

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