Psychosis in parkinsonism: an unorthodox approach

Marco Onofrj,1,2 Danilo Carrozzino,3,4 Aurelio D’Amico,1,2 Roberta Di Giacomo,1,2 Stefano Delli Pizzi,1 Astrid Thomas,1,2 Valeria Onofrj,5 John-Paul Taylor,6 Laura Bonanni1,2 1Department of Neuroscience Imaging and Clinical Sciences, University “G. d’Annunzio&rdquo...

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Autores principales:	Onofrj M, Carrozzino D, D'Amico A, Di Giacomo R, Delli Pizzi S, Thomas A, Onofrj V, Taylor JP, Bonanni L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Postencephalitic Parkinsonism Parkinson’s Disease psychosis Default Mode Network atypical parkinsonism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/dd821bb9c8664f9d8c24f0681a5fa2c7
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spelling	oai:doaj.org-article:dd821bb9c8664f9d8c24f0681a5fa2c72021-12-02T02:33:48ZPsychosis in parkinsonism: an unorthodox approach1178-2021https://doaj.org/article/dd821bb9c8664f9d8c24f0681a5fa2c72017-05-01T00:00:00Zhttps://www.dovepress.com/psychosis-in-parkinsonism-an-unorthodox-approach-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Marco Onofrj,1,2 Danilo Carrozzino,3,4 Aurelio D’Amico,1,2 Roberta Di Giacomo,1,2 Stefano Delli Pizzi,1 Astrid Thomas,1,2 Valeria Onofrj,5 John-Paul Taylor,6 Laura Bonanni1,2 1Department of Neuroscience Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti-Pescara, 2CE.S.I. University Foundation, 3Department of Psychological, Health, and Territorial Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy; 4Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University Hospital, Hillerød, Denmark; 5Department of Bioimaging, University Cattolica del Sacro Cuore, Rome, Italy; 6Institute of Neuroscience, Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne, Newcastle upon Tyne, UK Abstract: Psychosis in Parkinson’s disease (PD) is currently considered as the occurrence of hallucinations and delusions. The historical meaning of the term psychosis was, however, broader, encompassing a disorganization of both consciousness and personality, including behavior abnormalities, such as impulsive overactivity and catatonia, in complete definitions by the International Classification of Diseases-10 (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Our review is aimed at reminding that complex psychotic symptoms, including impulsive overactivity and somatoform disorders (the last being a recent controversial entity in PD), were carefully described in postencephalitic parkinsonism (PEP), many decades before dopaminergic treatment era, and are now described in other parkinsonisms than PD. Eminent neuropsychiatrists of the past century speculated that studying psychosis in PEP might highlight its mechanisms in other conditions. Yet, functional assessments were unavailable at the time. Therefore, the second part of our article reviews the studies of neural correlates of psychosis in parkinsonisms, by taking into account both theories on the narrative functions of the default mode network (DMN) and hypotheses on DMN modulation. Keywords: postencephalitic parkinsonism, Parkinson’s disease, psychosis, default mode network, atypical parkinsonismOnofrj MCarrozzino DD'Amico ADi Giacomo RDelli Pizzi SThomas AOnofrj VTaylor JPBonanni LDove Medical PressarticlePostencephalitic ParkinsonismParkinson’s DiseasepsychosisDefault Mode Networkatypical parkinsonismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1313-1330 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Postencephalitic Parkinsonism Parkinson’s Disease psychosis Default Mode Network atypical parkinsonism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Postencephalitic Parkinsonism Parkinson’s Disease psychosis Default Mode Network atypical parkinsonism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Onofrj M Carrozzino D D'Amico A Di Giacomo R Delli Pizzi S Thomas A Onofrj V Taylor JP Bonanni L Psychosis in parkinsonism: an unorthodox approach
description	Marco Onofrj,1,2 Danilo Carrozzino,3,4 Aurelio D’Amico,1,2 Roberta Di Giacomo,1,2 Stefano Delli Pizzi,1 Astrid Thomas,1,2 Valeria Onofrj,5 John-Paul Taylor,6 Laura Bonanni1,2 1Department of Neuroscience Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti-Pescara, 2CE.S.I. University Foundation, 3Department of Psychological, Health, and Territorial Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy; 4Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University Hospital, Hillerød, Denmark; 5Department of Bioimaging, University Cattolica del Sacro Cuore, Rome, Italy; 6Institute of Neuroscience, Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne, Newcastle upon Tyne, UK Abstract: Psychosis in Parkinson’s disease (PD) is currently considered as the occurrence of hallucinations and delusions. The historical meaning of the term psychosis was, however, broader, encompassing a disorganization of both consciousness and personality, including behavior abnormalities, such as impulsive overactivity and catatonia, in complete definitions by the International Classification of Diseases-10 (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Our review is aimed at reminding that complex psychotic symptoms, including impulsive overactivity and somatoform disorders (the last being a recent controversial entity in PD), were carefully described in postencephalitic parkinsonism (PEP), many decades before dopaminergic treatment era, and are now described in other parkinsonisms than PD. Eminent neuropsychiatrists of the past century speculated that studying psychosis in PEP might highlight its mechanisms in other conditions. Yet, functional assessments were unavailable at the time. Therefore, the second part of our article reviews the studies of neural correlates of psychosis in parkinsonisms, by taking into account both theories on the narrative functions of the default mode network (DMN) and hypotheses on DMN modulation. Keywords: postencephalitic parkinsonism, Parkinson’s disease, psychosis, default mode network, atypical parkinsonism
format	article
author	Onofrj M Carrozzino D D'Amico A Di Giacomo R Delli Pizzi S Thomas A Onofrj V Taylor JP Bonanni L
author_facet	Onofrj M Carrozzino D D'Amico A Di Giacomo R Delli Pizzi S Thomas A Onofrj V Taylor JP Bonanni L
author_sort	Onofrj M
title	Psychosis in parkinsonism: an unorthodox approach
title_short	Psychosis in parkinsonism: an unorthodox approach
title_full	Psychosis in parkinsonism: an unorthodox approach
title_fullStr	Psychosis in parkinsonism: an unorthodox approach
title_full_unstemmed	Psychosis in parkinsonism: an unorthodox approach
title_sort	psychosis in parkinsonism: an unorthodox approach
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/dd821bb9c8664f9d8c24f0681a5fa2c7
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_version_	1718402443376590848

Psychosis in parkinsonism: an unorthodox approach

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