Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels

Simple microfluidic systems for handling large particles such as three-dimensional (3D) cultured cells, microcapsules, and animalcules have contributed to the advancement of biology. However, obtaining a highly integrated microfluidic device for handling large particles is difficult because there ar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maho Kaminaga, Tadashi Ishida, Toru Omata
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microfluidic device pneumatic microvalve inclined lithography Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/dd86def846934339aa78919b829f5422
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd86def846934339aa78919b829f5422
record_format	dspace
spelling	oai:doaj.org-article:dd86def846934339aa78919b829f54222021-11-25T18:23:43ZMicrovalve with Trapezoid-Shaped Cross-Section for Deep Microchannels10.3390/mi121114032072-666Xhttps://doaj.org/article/dd86def846934339aa78919b829f54222021-11-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1403https://doaj.org/toc/2072-666XSimple microfluidic systems for handling large particles such as three-dimensional (3D) cultured cells, microcapsules, and animalcules have contributed to the advancement of biology. However, obtaining a highly integrated microfluidic device for handling large particles is difficult because there are no suitable microvalves for deep microchannels. Therefore, this study proposes a microvalve with a trapezoid-shaped cross-section to close a deep microchannel. The proposed microvalve can close a 350 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m deep microchannel, which is suitable for handling hundreds of micrometer-scale particles. A double-inclined lithography process was used to fabricate the trapezoid-shaped cross-section. The microvalve was fabricated by bonding three polydimethylsiloxane layers: a trapezoid-shaped liquid channel layer, a membrane, and a pneumatic channel layer. The pneumatic balloon, consisting of the membrane and the pneumatic channel, was located beneath a trapezoid-shaped cross-section microchannel. The valve was operated by the application of pneumatic pressure to the pneumatic channel. We experimentally confirmed that the expansion of the pneumatic balloon could close the 350 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m deep microchannel.Maho KaminagaTadashi IshidaToru OmataMDPI AGarticlemicrofluidic devicepneumatic microvalveinclined lithographyMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1403, p 1403 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microfluidic device pneumatic microvalve inclined lithography Mechanical engineering and machinery TJ1-1570
spellingShingle	microfluidic device pneumatic microvalve inclined lithography Mechanical engineering and machinery TJ1-1570 Maho Kaminaga Tadashi Ishida Toru Omata Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
description	Simple microfluidic systems for handling large particles such as three-dimensional (3D) cultured cells, microcapsules, and animalcules have contributed to the advancement of biology. However, obtaining a highly integrated microfluidic device for handling large particles is difficult because there are no suitable microvalves for deep microchannels. Therefore, this study proposes a microvalve with a trapezoid-shaped cross-section to close a deep microchannel. The proposed microvalve can close a 350 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m deep microchannel, which is suitable for handling hundreds of micrometer-scale particles. A double-inclined lithography process was used to fabricate the trapezoid-shaped cross-section. The microvalve was fabricated by bonding three polydimethylsiloxane layers: a trapezoid-shaped liquid channel layer, a membrane, and a pneumatic channel layer. The pneumatic balloon, consisting of the membrane and the pneumatic channel, was located beneath a trapezoid-shaped cross-section microchannel. The valve was operated by the application of pneumatic pressure to the pneumatic channel. We experimentally confirmed that the expansion of the pneumatic balloon could close the 350 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m deep microchannel.
format	article
author	Maho Kaminaga Tadashi Ishida Toru Omata
author_facet	Maho Kaminaga Tadashi Ishida Toru Omata
author_sort	Maho Kaminaga
title	Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
title_short	Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
title_full	Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
title_fullStr	Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
title_full_unstemmed	Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels
title_sort	microvalve with trapezoid-shaped cross-section for deep microchannels
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dd86def846934339aa78919b829f5422
work_keys_str_mv	AT mahokaminaga microvalvewithtrapezoidshapedcrosssectionfordeepmicrochannels AT tadashiishida microvalvewithtrapezoidshapedcrosssectionfordeepmicrochannels AT toruomata microvalvewithtrapezoidshapedcrosssectionfordeepmicrochannels
_version_	1718411229126459392

Microvalve with Trapezoid-Shaped Cross-Section for Deep Microchannels

Ejemplares similares