Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging

Polyhedral oligomeric silsesquioxanes (POSS) have attracted considerable attention in the design of novel organic-inorganic hybrid materials with high performance capabilities. Features such as their well-defined nanoscale structure, chemical tunability, and biocompatibility make POSS an ideal build...

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Autores principales:	Paula Loman-Cortes, Tamanna Binte Huq, Juan L. Vivero-Escoto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyhedral oligomeric silsesquioxane (POSS) drug delivery systems (DDS) photodynamic therapy (PDT) biomedical applications imaging Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/dd8756a8a45c443cbca843f0fd7e0841
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spelling	oai:doaj.org-article:dd8756a8a45c443cbca843f0fd7e08412021-11-11T18:27:47ZUse of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging10.3390/molecules262164531420-3049https://doaj.org/article/dd8756a8a45c443cbca843f0fd7e08412021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6453https://doaj.org/toc/1420-3049Polyhedral oligomeric silsesquioxanes (POSS) have attracted considerable attention in the design of novel organic-inorganic hybrid materials with high performance capabilities. Features such as their well-defined nanoscale structure, chemical tunability, and biocompatibility make POSS an ideal building block to fabricate hybrid materials for biomedical applications. This review highlights recent advances in the application of POSS-based hybrid materials, with particular emphasis on drug delivery, photodynamic therapy and bioimaging. The design and synthesis of POSS-based materials is described, along with the current methods for controlling their chemical functionalization for biomedical applications. We summarize the advantages of using POSS for several drug delivery applications. We also describe the current progress on using POSS-based materials to improve photodynamic therapies. The use of POSS for delivery of contrast agents or as a passivating agent for nanoprobes is also summarized. We envision that POSS-based hybrid materials have great potential for a variety of biomedical applications including drug delivery, photodynamic therapy and bioimaging.Paula Loman-CortesTamanna Binte HuqJuan L. Vivero-EscotoMDPI AGarticlepolyhedral oligomeric silsesquioxane (POSS)drug delivery systems (DDS)photodynamic therapy (PDT)biomedical applicationsimagingOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6453, p 6453 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyhedral oligomeric silsesquioxane (POSS) drug delivery systems (DDS) photodynamic therapy (PDT) biomedical applications imaging Organic chemistry QD241-441
spellingShingle	polyhedral oligomeric silsesquioxane (POSS) drug delivery systems (DDS) photodynamic therapy (PDT) biomedical applications imaging Organic chemistry QD241-441 Paula Loman-Cortes Tamanna Binte Huq Juan L. Vivero-Escoto Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
description	Polyhedral oligomeric silsesquioxanes (POSS) have attracted considerable attention in the design of novel organic-inorganic hybrid materials with high performance capabilities. Features such as their well-defined nanoscale structure, chemical tunability, and biocompatibility make POSS an ideal building block to fabricate hybrid materials for biomedical applications. This review highlights recent advances in the application of POSS-based hybrid materials, with particular emphasis on drug delivery, photodynamic therapy and bioimaging. The design and synthesis of POSS-based materials is described, along with the current methods for controlling their chemical functionalization for biomedical applications. We summarize the advantages of using POSS for several drug delivery applications. We also describe the current progress on using POSS-based materials to improve photodynamic therapies. The use of POSS for delivery of contrast agents or as a passivating agent for nanoprobes is also summarized. We envision that POSS-based hybrid materials have great potential for a variety of biomedical applications including drug delivery, photodynamic therapy and bioimaging.
format	article
author	Paula Loman-Cortes Tamanna Binte Huq Juan L. Vivero-Escoto
author_facet	Paula Loman-Cortes Tamanna Binte Huq Juan L. Vivero-Escoto
author_sort	Paula Loman-Cortes
title	Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
title_short	Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
title_full	Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
title_fullStr	Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
title_full_unstemmed	Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging
title_sort	use of polyhedral oligomeric silsesquioxane (poss) in drug delivery, photodynamic therapy and bioimaging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dd8756a8a45c443cbca843f0fd7e0841
work_keys_str_mv	AT paulalomancortes useofpolyhedraloligomericsilsesquioxanepossindrugdeliveryphotodynamictherapyandbioimaging AT tamannabintehuq useofpolyhedraloligomericsilsesquioxanepossindrugdeliveryphotodynamictherapyandbioimaging AT juanlviveroescoto useofpolyhedraloligomericsilsesquioxanepossindrugdeliveryphotodynamictherapyandbioimaging
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Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging

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