EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS

Abstract. The objective of this study was to determine efficacy and safety of melatonin administered in addition to conventional atopic dermatitis treatment. Study design: open randomized parallel group study. Patients and treatment: Forty-six patients with exacerbation of moderate-to-severe atopic...

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Autores principales:	V. S. Shirinsky, V. M. Nepomnyashikh, M. I. Leonova, O. L. Krugleeva, V. S. Kozhevnikov, N. Yu. Solovyova, A. V. Shurlygina, G. I. Litvinenko, I. V. Shirinsky, O. A. Malysheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	melatonin immune status atopic dermatitis treatment efficacy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/dd8914fdf2b04aa4b39b32fa1c9ff084
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spelling	oai:doaj.org-article:dd8914fdf2b04aa4b39b32fa1c9ff0842021-11-18T08:03:42ZEFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS1563-06252313-741X10.15789/1563-0625-2006-5-6-707-714https://doaj.org/article/dd8914fdf2b04aa4b39b32fa1c9ff0842014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/579https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The objective of this study was to determine efficacy and safety of melatonin administered in addition to conventional atopic dermatitis treatment. Study design: open randomized parallel group study. Patients and treatment: Forty-six patients with exacerbation of moderate-to-severe atopic dermatitis were included into the study. The patients were randomized, to receive either complex conventional treatment, or conventional treatment plus melatonin at a daily dose of 3 mg, being administered at 9 P.M. Primary endpoint of the study: Severity scoring using SCORAD index. Assessment of pharmacological effects included counting functional evaluation of T-cells, B-cells and phagocytes, as well as morning and evening serum levels of IgE, IL-4 and IFN-γ. Results. In melatonin group, a statistically significant SCORAD index reduction was revealed, as compared with conventionally treated group (84% vs 60%). Addition of melatonin to conventional treatment caused a 63 per cent decrease in relative risks of unfavorable outcome, defined as absence of 20 per cent improvement by the SCORAD scale. Clinical improvement in melatonin group was associated with increase in CD8+cell counts, IgM levels and indices of Fc-dependent monocyte and neutrophil phagocytosis. Circulating IgE and IL-4 levels did significantly decrease. In melatonin group, there were significant differences between the morning and evening counts of CD3+, CD4+, CD8+, CD16+ cells, like as levels of circulating IFN-γ. These preliminary data suggest efficacy of melatonin administration in the patients with atopic dermatitis. Further research is needed to confirm these results.V. S. ShirinskyV. M. NepomnyashikhM. I. LeonovaO. L. KrugleevaV. S. KozhevnikovN. Yu. SolovyovaA. V. ShurlyginaG. I. LitvinenkoI. V. ShirinskyO. A. MalyshevaSPb RAACIarticlemelatoninimmune statusatopic dermatitistreatment efficacyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 707-714 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	melatonin immune status atopic dermatitis treatment efficacy Immunologic diseases. Allergy RC581-607
spellingShingle	melatonin immune status atopic dermatitis treatment efficacy Immunologic diseases. Allergy RC581-607 V. S. Shirinsky V. M. Nepomnyashikh M. I. Leonova O. L. Krugleeva V. S. Kozhevnikov N. Yu. Solovyova A. V. Shurlygina G. I. Litvinenko I. V. Shirinsky O. A. Malysheva EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
description	Abstract. The objective of this study was to determine efficacy and safety of melatonin administered in addition to conventional atopic dermatitis treatment. Study design: open randomized parallel group study. Patients and treatment: Forty-six patients with exacerbation of moderate-to-severe atopic dermatitis were included into the study. The patients were randomized, to receive either complex conventional treatment, or conventional treatment plus melatonin at a daily dose of 3 mg, being administered at 9 P.M. Primary endpoint of the study: Severity scoring using SCORAD index. Assessment of pharmacological effects included counting functional evaluation of T-cells, B-cells and phagocytes, as well as morning and evening serum levels of IgE, IL-4 and IFN-γ. Results. In melatonin group, a statistically significant SCORAD index reduction was revealed, as compared with conventionally treated group (84% vs 60%). Addition of melatonin to conventional treatment caused a 63 per cent decrease in relative risks of unfavorable outcome, defined as absence of 20 per cent improvement by the SCORAD scale. Clinical improvement in melatonin group was associated with increase in CD8+cell counts, IgM levels and indices of Fc-dependent monocyte and neutrophil phagocytosis. Circulating IgE and IL-4 levels did significantly decrease. In melatonin group, there were significant differences between the morning and evening counts of CD3+, CD4+, CD8+, CD16+ cells, like as levels of circulating IFN-γ. These preliminary data suggest efficacy of melatonin administration in the patients with atopic dermatitis. Further research is needed to confirm these results.
format	article
author	V. S. Shirinsky V. M. Nepomnyashikh M. I. Leonova O. L. Krugleeva V. S. Kozhevnikov N. Yu. Solovyova A. V. Shurlygina G. I. Litvinenko I. V. Shirinsky O. A. Malysheva
author_facet	V. S. Shirinsky V. M. Nepomnyashikh M. I. Leonova O. L. Krugleeva V. S. Kozhevnikov N. Yu. Solovyova A. V. Shurlygina G. I. Litvinenko I. V. Shirinsky O. A. Malysheva
author_sort	V. S. Shirinsky
title	EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
title_short	EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
title_full	EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
title_fullStr	EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
title_full_unstemmed	EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS
title_sort	efficiency and safety of melatonin administration in the patients with atopic dermatitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/dd8914fdf2b04aa4b39b32fa1c9ff084
work_keys_str_mv	AT vsshirinsky efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT vmnepomnyashikh efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT mileonova efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT olkrugleeva efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT vskozhevnikov efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT nyusolovyova efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT avshurlygina efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT gilitvinenko efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT ivshirinsky efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis AT oamalysheva efficiencyandsafetyofmelatoninadministrationinthepatientswithatopicdermatitis
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EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS

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