Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis

Abstract Ototoxic medications can lead to significant morbidity. Thus, pre-marketing clinical trials have assessed new drugs that have ototoxic potential. Nevertheless, several ototoxic side effects of drugs may remain undetected. Hence, we sought to retrospectively investigate the potential risk of...

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Autores principales:	Suehyun Lee, Jaehun Cha, Jong-Yeup Kim, Gil Myeong Son, Dong-Kyu Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd894c6b9ff841efac4fb3b5e65d0ed3
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spelling	oai:doaj.org-article:dd894c6b9ff841efac4fb3b5e65d0ed32021-12-02T15:39:50ZDetection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis10.1038/s41598-021-93522-z2045-2322https://doaj.org/article/dd894c6b9ff841efac4fb3b5e65d0ed32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93522-zhttps://doaj.org/toc/2045-2322Abstract Ototoxic medications can lead to significant morbidity. Thus, pre-marketing clinical trials have assessed new drugs that have ototoxic potential. Nevertheless, several ototoxic side effects of drugs may remain undetected. Hence, we sought to retrospectively investigate the potential risk of ototoxic adverse drug reactions among commonly used drugs via a longitudinal cohort study. An electronic health records-based data analysis with a propensity-matched comparator group was carried out. This study was conducted using the MetaNurse algorithm for standard nursing statements on electronic healthcare records and the National Sample Cohort obtained from the South Korea National Health Insurance Service. Five target drugs capable of causing ototoxic adverse drug reactions were identified using MetaNurse; two drugs were excluded after database-based analysis because of the absence of bilateral hearing loss events in patients. Survival analysis, log-rank test, and Cox proportional hazards regression models were used to calculate the incidence, survival rate, and hazard ratio of bilateral hearing loss among patients who were prescribed candidate ototoxic drugs. The adjusted hazard ratio of bilateral hearing loss was 1.31 (1.03–1.68), 2.20 (1.05–4.60), and 2.26 (1.18–4.33) in cimetidine, hydroxyzine, and sucralfate users, respectively. Our results indicated that hydroxyzine and sucralfate may cause ototoxic adverse drug reactions in patients. Thus, clinicians should consider avoiding co-administration of these drugs with other well-confirmed ototoxic drugs should be emphasized.Suehyun LeeJaehun ChaJong-Yeup KimGil Myeong SonDong-Kyu KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suehyun Lee Jaehun Cha Jong-Yeup Kim Gil Myeong Son Dong-Kyu Kim Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
description	Abstract Ototoxic medications can lead to significant morbidity. Thus, pre-marketing clinical trials have assessed new drugs that have ototoxic potential. Nevertheless, several ototoxic side effects of drugs may remain undetected. Hence, we sought to retrospectively investigate the potential risk of ototoxic adverse drug reactions among commonly used drugs via a longitudinal cohort study. An electronic health records-based data analysis with a propensity-matched comparator group was carried out. This study was conducted using the MetaNurse algorithm for standard nursing statements on electronic healthcare records and the National Sample Cohort obtained from the South Korea National Health Insurance Service. Five target drugs capable of causing ototoxic adverse drug reactions were identified using MetaNurse; two drugs were excluded after database-based analysis because of the absence of bilateral hearing loss events in patients. Survival analysis, log-rank test, and Cox proportional hazards regression models were used to calculate the incidence, survival rate, and hazard ratio of bilateral hearing loss among patients who were prescribed candidate ototoxic drugs. The adjusted hazard ratio of bilateral hearing loss was 1.31 (1.03–1.68), 2.20 (1.05–4.60), and 2.26 (1.18–4.33) in cimetidine, hydroxyzine, and sucralfate users, respectively. Our results indicated that hydroxyzine and sucralfate may cause ototoxic adverse drug reactions in patients. Thus, clinicians should consider avoiding co-administration of these drugs with other well-confirmed ototoxic drugs should be emphasized.
format	article
author	Suehyun Lee Jaehun Cha Jong-Yeup Kim Gil Myeong Son Dong-Kyu Kim
author_facet	Suehyun Lee Jaehun Cha Jong-Yeup Kim Gil Myeong Son Dong-Kyu Kim
author_sort	Suehyun Lee
title	Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
title_short	Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
title_full	Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
title_fullStr	Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
title_full_unstemmed	Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
title_sort	detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd894c6b9ff841efac4fb3b5e65d0ed3
work_keys_str_mv	AT suehyunlee detectionofunknownototoxicadversedrugreactionsanelectronichealthcarerecordbasedlongitudinalnationwidecohortanalysis AT jaehuncha detectionofunknownototoxicadversedrugreactionsanelectronichealthcarerecordbasedlongitudinalnationwidecohortanalysis AT jongyeupkim detectionofunknownototoxicadversedrugreactionsanelectronichealthcarerecordbasedlongitudinalnationwidecohortanalysis AT gilmyeongson detectionofunknownototoxicadversedrugreactionsanelectronichealthcarerecordbasedlongitudinalnationwidecohortanalysis AT dongkyukim detectionofunknownototoxicadversedrugreactionsanelectronichealthcarerecordbasedlongitudinalnationwidecohortanalysis
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Detection of unknown ototoxic adverse drug reactions: an electronic healthcare record-based longitudinal nationwide cohort analysis

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