Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis

Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis

Abstract Rheumatoid Arthritis (RA) is a chronic autoimmune disease associated with inflammation and joint remodeling. Adenosine deaminase (ADA), a risk factor in RA, degrades adenosine, an anti-inflammatory molecule, resulting in an inflammatory bias. We present an integrative analysis of clinical d...

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Main Authors: Sai Krishna Srimadh Bhagavatham, Prakash Khanchandani, Vishnu Kannan, Damodaram Potikuri, Divya Sridharan, Sujith Kumar Pulukool, Ashwin Ashok Naik, Rajesh Babu Dandamudi, Sai Mangala Divi, Ashish Pargaonkar, Rahul Ray, Saibharath Simha Reddy Santha, Polani B. Seshagiri, K. Narasimhan, Narsimulu Gumdal, Venketesh Sivaramakrishnan
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/dd8e8a9f1ef24cb9976f5b984cc75f22
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