Conserved expression signatures between medaka and human pigment cell tumors.

Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such rel...

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Autores principales:	Manfred Schartl, Susanne Kneitz, Brigitta Wilde, Toni Wagner, Christiaan V Henkel, Herman P Spaink, Svenja Meierjohann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd90378d3387491485ca1845b573cf04
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spelling	oai:doaj.org-article:dd90378d3387491485ca1845b573cf042021-11-18T07:16:42ZConserved expression signatures between medaka and human pigment cell tumors.1932-620310.1371/journal.pone.0037880https://doaj.org/article/dd90378d3387491485ca1845b573cf042012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22693581/?tool=EBIhttps://doaj.org/toc/1932-6203Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massive parallel sequencing of different types of melanoma from medaka were generated and compared to microarray datasets from zebrafish and human melanoma. This revealed molecular conservation at various levels between fish models and human tumors providing a useful strategy for identifying expression signatures strongly associated with disease phenotypes and uncovering new melanoma molecules.Manfred SchartlSusanne KneitzBrigitta WildeToni WagnerChristiaan V HenkelHerman P SpainkSvenja MeierjohannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37880 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manfred Schartl Susanne Kneitz Brigitta Wilde Toni Wagner Christiaan V Henkel Herman P Spaink Svenja Meierjohann Conserved expression signatures between medaka and human pigment cell tumors.
description	Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massive parallel sequencing of different types of melanoma from medaka were generated and compared to microarray datasets from zebrafish and human melanoma. This revealed molecular conservation at various levels between fish models and human tumors providing a useful strategy for identifying expression signatures strongly associated with disease phenotypes and uncovering new melanoma molecules.
format	article
author	Manfred Schartl Susanne Kneitz Brigitta Wilde Toni Wagner Christiaan V Henkel Herman P Spaink Svenja Meierjohann
author_facet	Manfred Schartl Susanne Kneitz Brigitta Wilde Toni Wagner Christiaan V Henkel Herman P Spaink Svenja Meierjohann
author_sort	Manfred Schartl
title	Conserved expression signatures between medaka and human pigment cell tumors.
title_short	Conserved expression signatures between medaka and human pigment cell tumors.
title_full	Conserved expression signatures between medaka and human pigment cell tumors.
title_fullStr	Conserved expression signatures between medaka and human pigment cell tumors.
title_full_unstemmed	Conserved expression signatures between medaka and human pigment cell tumors.
title_sort	conserved expression signatures between medaka and human pigment cell tumors.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/dd90378d3387491485ca1845b573cf04
work_keys_str_mv	AT manfredschartl conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT susannekneitz conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT brigittawilde conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT toniwagner conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT christiaanvhenkel conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT hermanpspaink conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors AT svenjameierjohann conservedexpressionsignaturesbetweenmedakaandhumanpigmentcelltumors
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Conserved expression signatures between medaka and human pigment cell tumors.

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