Pharmacogenetics and nutritional supplementation in age-related macular degeneration

Blake M Hampton, Jaclyn L Kovach, Stephen G Schwartz Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: The Age-Related Eye Disease Study (AREDS) recommended treatment with antioxidants plus zinc in patients wi...

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Autores principales:	Hampton BM, Kovach JL, Schwartz SG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/dd903f38812b4b7881c5af958a21b356
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spelling	oai:doaj.org-article:dd903f38812b4b7881c5af958a21b3562021-12-02T02:33:49ZPharmacogenetics and nutritional supplementation in age-related macular degeneration1177-5483https://doaj.org/article/dd903f38812b4b7881c5af958a21b3562015-05-01T00:00:00Zhttp://www.dovepress.com/pharmacogenetics-and-nutritional-supplementation-in-age-related-macula-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Blake M Hampton, Jaclyn L Kovach, Stephen G Schwartz Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: The Age-Related Eye Disease Study (AREDS) recommended treatment with antioxidants plus zinc in patients with intermediate or advanced age-related macular degeneration in order to reduce progression risks. Recent pharmacogenetic studies have reported differences in treatment outcomes with respect to variants in genes for CFH and ARMS2, although the treatment recommendations based on these differences are controversial. Different retrospective analyses of subsets of patients from the same AREDS trial have drawn different conclusions. The practicing clinician, who is not an expert on genetics, clinical trial design, or statistical analysis, may be uncertain how to interpret these results. Based on the balance of the available literature, we suggest not changing established practice recommendations until additional evidence from clinical trials becomes available. Keywords: Age-Related Eye Disease Study (AREDS), age-related macular degeneration, age-related maculopathy susceptibility 2 (ARMS2), complement factor H (CFH), pharmacogenetics, randomized clinical trial (RCT)Hampton BMKovach JLSchwartz SGDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 873-876 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Hampton BM Kovach JL Schwartz SG Pharmacogenetics and nutritional supplementation in age-related macular degeneration
description	Blake M Hampton, Jaclyn L Kovach, Stephen G Schwartz Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: The Age-Related Eye Disease Study (AREDS) recommended treatment with antioxidants plus zinc in patients with intermediate or advanced age-related macular degeneration in order to reduce progression risks. Recent pharmacogenetic studies have reported differences in treatment outcomes with respect to variants in genes for CFH and ARMS2, although the treatment recommendations based on these differences are controversial. Different retrospective analyses of subsets of patients from the same AREDS trial have drawn different conclusions. The practicing clinician, who is not an expert on genetics, clinical trial design, or statistical analysis, may be uncertain how to interpret these results. Based on the balance of the available literature, we suggest not changing established practice recommendations until additional evidence from clinical trials becomes available. Keywords: Age-Related Eye Disease Study (AREDS), age-related macular degeneration, age-related maculopathy susceptibility 2 (ARMS2), complement factor H (CFH), pharmacogenetics, randomized clinical trial (RCT)
format	article
author	Hampton BM Kovach JL Schwartz SG
author_facet	Hampton BM Kovach JL Schwartz SG
author_sort	Hampton BM
title	Pharmacogenetics and nutritional supplementation in age-related macular degeneration
title_short	Pharmacogenetics and nutritional supplementation in age-related macular degeneration
title_full	Pharmacogenetics and nutritional supplementation in age-related macular degeneration
title_fullStr	Pharmacogenetics and nutritional supplementation in age-related macular degeneration
title_full_unstemmed	Pharmacogenetics and nutritional supplementation in age-related macular degeneration
title_sort	pharmacogenetics and nutritional supplementation in age-related macular degeneration
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/dd903f38812b4b7881c5af958a21b356
work_keys_str_mv	AT hamptonbm pharmacogeneticsandnutritionalsupplementationinagerelatedmaculardegeneration AT kovachjl pharmacogeneticsandnutritionalsupplementationinagerelatedmaculardegeneration AT schwartzsg pharmacogeneticsandnutritionalsupplementationinagerelatedmaculardegeneration
_version_	1718402443563237376

Pharmacogenetics and nutritional supplementation in age-related macular degeneration

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