miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2

Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investiga...

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Autores principales:	Yang Peng, Han Jianhua, Li Shigeng, Luo Shaoning, Tu Xusheng, Ye Zhiqiang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	sepsis mir-128-3p tgfbr2 apoptosis inflammation Medicine R
Acceso en línea:	https://doaj.org/article/dd90e9c345c24a9eb88ad8ac91237f3a
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spelling	oai:doaj.org-article:dd90e9c345c24a9eb88ad8ac91237f3a2021-12-05T14:10:54ZmiR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR22391-546310.1515/med-2021-0222https://doaj.org/article/dd90e9c345c24a9eb88ad8ac91237f3a2021-02-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0222https://doaj.org/toc/2391-5463Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis.Yang PengHan JianhuaLi ShigengLuo ShaoningTu XushengYe ZhiqiangDe Gruyterarticlesepsismir-128-3ptgfbr2apoptosisinflammationMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 274-283 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sepsis mir-128-3p tgfbr2 apoptosis inflammation Medicine R
spellingShingle	sepsis mir-128-3p tgfbr2 apoptosis inflammation Medicine R Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
description	Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis.
format	article
author	Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang
author_facet	Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang
author_sort	Yang Peng
title	miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
title_short	miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
title_full	miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
title_fullStr	miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
title_full_unstemmed	miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
title_sort	mir-128-3p inhibits apoptosis and inflammation in lps-induced sepsis by targeting tgfbr2
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/dd90e9c345c24a9eb88ad8ac91237f3a
work_keys_str_mv	AT yangpeng mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2 AT hanjianhua mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2 AT lishigeng mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2 AT luoshaoning mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2 AT tuxusheng mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2 AT yezhiqiang mir1283pinhibitsapoptosisandinflammationinlpsinducedsepsisbytargetingtgfbr2
_version_	1718371631647162368

miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2

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