Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose up...

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Autores principales:	Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou, George A. Garinis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd93c72da8e9418589b147b5bd5f512a
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spelling	oai:doaj.org-article:dd93c72da8e9418589b147b5bd5f512a2021-12-02T14:40:39ZTissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage10.1038/s41467-019-13894-92041-1723https://doaj.org/article/dd93c72da8e9418589b147b5bd5f512a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13894-9https://doaj.org/toc/2041-1723DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose uptake in recipient cells, leading to increased inflammation.Evi GoulielmakiAnna IoannidouMaria TsekrekouKalliopi StratigiIoanna K. PoutakidouKaterina GkirtzimanakiMichalis AivaliotisKonstantinos EvangelouPantelis TopalisJanine AltmüllerVassilis G. GorgoulisGeorgia ChatzinikolaouGeorge A. GarinisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evi Goulielmaki Anna Ioannidou Maria Tsekrekou Kalliopi Stratigi Ioanna K. Poutakidou Katerina Gkirtzimanaki Michalis Aivaliotis Konstantinos Evangelou Pantelis Topalis Janine Altmüller Vassilis G. Gorgoulis Georgia Chatzinikolaou George A. Garinis Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
description	DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose uptake in recipient cells, leading to increased inflammation.
format	article
author	Evi Goulielmaki Anna Ioannidou Maria Tsekrekou Kalliopi Stratigi Ioanna K. Poutakidou Katerina Gkirtzimanaki Michalis Aivaliotis Konstantinos Evangelou Pantelis Topalis Janine Altmüller Vassilis G. Gorgoulis Georgia Chatzinikolaou George A. Garinis
author_facet	Evi Goulielmaki Anna Ioannidou Maria Tsekrekou Kalliopi Stratigi Ioanna K. Poutakidou Katerina Gkirtzimanaki Michalis Aivaliotis Konstantinos Evangelou Pantelis Topalis Janine Altmüller Vassilis G. Gorgoulis Georgia Chatzinikolaou George A. Garinis
author_sort	Evi Goulielmaki
title	Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
title_short	Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
title_full	Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
title_fullStr	Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
title_full_unstemmed	Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
title_sort	tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon dna damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dd93c72da8e9418589b147b5bd5f512a
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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

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