Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose up...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou, George A. Garinis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/dd93c72da8e9418589b147b5bd5f512a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/dd93c72da8e9418589b147b5bd5f512a

Ejemplares similares