Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A

The current research aimed to study clinical, hematological and pathological changes occurred due to experimentally challenged rabbits with Pasteurella multocida type A. Twelve healthy Pasteurella multocida free rabbits were divided into control and challenged groups. Rabbits of the challenged group...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatma Mohamed, Abeer El Hendy, Ahmed Khalaf Hassan
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2020
Materias:	pasteurella multocida hematological parameters histopathological lesions Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/dd9568a3799a4984a53afdd86447e1bf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd9568a3799a4984a53afdd86447e1bf
record_format	dspace
spelling	oai:doaj.org-article:dd9568a3799a4984a53afdd86447e1bf2021-12-02T09:11:55Z Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A10.21608/SVU.2020.28129.10482535-18262535-1877https://doaj.org/article/dd9568a3799a4984a53afdd86447e1bf2020-05-01T00:00:00Zhttps://svu.journals.ekb.eg/article_87607.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877The current research aimed to study clinical, hematological and pathological changes occurred due to experimentally challenged rabbits with Pasteurella multocida type A. Twelve healthy Pasteurella multocida free rabbits were divided into control and challenged groups. Rabbits of the challenged group were intra-nasally inoculated with 0.5 ml of 1x105 CFU of Pasteurella multocida type A, while rabbits of the control group were inoculated with 0.5 ml of brain heart infusion broth (BHI). Clinical signs, hematological parameters and histopathological lesions were recoded for 14 days. Rabbits of challenged group showed nasal rubbing with minimal mucus discharge, conjunctivitis and reduction in spontaneous activity, but no mortality occurred. Hematologically, there was highly significant low RBCs count with concomitant significantly reduction of PCV in challenged rabbits, but hemoglobin concentration was insignificantly low in challenged animals as compared to control. Although, there was insignificant increase of WBCs count in challenged group, neutrophils and monocytes recorded significant and highly significant high value in challenged rabbits than control, respectively. Challenged rabbits, however demonstrated highly significant lymphopenia, but other blood parameters did not show any significant differences between challenged and control rabbits. Histopathologically, challenged animals showed meningitis, congestion and degenerative changes in respiratory epithelium, bronchopneumonia, vacuolar degeneration of hepatocytes and vascular changes in heart and spleen. Conclusively, the current study verified that challenging rabbits with Pasteurella multocida serotype A was not lethal and although it was essentially pneumotropic in nature, it caused lesions in other visceral organs, which in absence of bacteremia, could be caused by bacterial endotoxin liberated during disease pathogenesis. Fatma MohamedAbeer El HendyAhmed Khalaf HassanSouth Valley Universityarticlepasteurella multocidahematological parametershistopathological lesionsAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 3, Iss 2, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pasteurella multocida hematological parameters histopathological lesions Agriculture S Veterinary medicine SF600-1100
spellingShingle	pasteurella multocida hematological parameters histopathological lesions Agriculture S Veterinary medicine SF600-1100 Fatma Mohamed Abeer El Hendy Ahmed Khalaf Hassan Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
description	The current research aimed to study clinical, hematological and pathological changes occurred due to experimentally challenged rabbits with Pasteurella multocida type A. Twelve healthy Pasteurella multocida free rabbits were divided into control and challenged groups. Rabbits of the challenged group were intra-nasally inoculated with 0.5 ml of 1x105 CFU of Pasteurella multocida type A, while rabbits of the control group were inoculated with 0.5 ml of brain heart infusion broth (BHI). Clinical signs, hematological parameters and histopathological lesions were recoded for 14 days. Rabbits of challenged group showed nasal rubbing with minimal mucus discharge, conjunctivitis and reduction in spontaneous activity, but no mortality occurred. Hematologically, there was highly significant low RBCs count with concomitant significantly reduction of PCV in challenged rabbits, but hemoglobin concentration was insignificantly low in challenged animals as compared to control. Although, there was insignificant increase of WBCs count in challenged group, neutrophils and monocytes recorded significant and highly significant high value in challenged rabbits than control, respectively. Challenged rabbits, however demonstrated highly significant lymphopenia, but other blood parameters did not show any significant differences between challenged and control rabbits. Histopathologically, challenged animals showed meningitis, congestion and degenerative changes in respiratory epithelium, bronchopneumonia, vacuolar degeneration of hepatocytes and vascular changes in heart and spleen. Conclusively, the current study verified that challenging rabbits with Pasteurella multocida serotype A was not lethal and although it was essentially pneumotropic in nature, it caused lesions in other visceral organs, which in absence of bacteremia, could be caused by bacterial endotoxin liberated during disease pathogenesis.
format	article
author	Fatma Mohamed Abeer El Hendy Ahmed Khalaf Hassan
author_facet	Fatma Mohamed Abeer El Hendy Ahmed Khalaf Hassan
author_sort	Fatma Mohamed
title	Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
title_short	Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
title_full	Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
title_fullStr	Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
title_full_unstemmed	Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A
title_sort	clinicopathological and hematological changes in consequence to experimental infection of rabbits with pasteurella multocida type a
publisher	South Valley University
publishDate	2020
url	https://doaj.org/article/dd9568a3799a4984a53afdd86447e1bf
work_keys_str_mv	AT fatmamohamed clinicopathologicalandhematologicalchangesinconsequencetoexperimentalinfectionofrabbitswithpasteurellamultocidatypea AT abeerelhendy clinicopathologicalandhematologicalchangesinconsequencetoexperimentalinfectionofrabbitswithpasteurellamultocidatypea AT ahmedkhalafhassan clinicopathologicalandhematologicalchangesinconsequencetoexperimentalinfectionofrabbitswithpasteurellamultocidatypea
_version_	1718398215531790336

Clinicopathological and Hematological Changes in Consequence to Experimental Infection of Rabbits with Pasteurella Multocida Type A

Ejemplares similares