Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes

Noemi Burguera-Giménez,1– 3 Santiago García-Lázaro,2 Enrique España-Gregori,4,5 Roberto Gallego-Pinazo,6 Neus Burguera-Giménez,2 Manuel Rodríguez-Vallejo,3 Gowtham Jonna1 1Ophthalmology Department, Retina Research Center, Au...

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Autores principales:	Burguera-Giménez N, García-Lázaro S, España-Gregori E, Gallego-Pinazo R, Rodríguez-Vallejo M, Jonna G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	geographic atrophy age-related macular degeneration reading speed visual function quality of life Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/dd97357fdfcc4788ac2f11972c3d3a86
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spelling	oai:doaj.org-article:dd97357fdfcc4788ac2f11972c3d3a862021-12-02T10:31:58ZMultimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes1177-5483https://doaj.org/article/dd97357fdfcc4788ac2f11972c3d3a862020-06-01T00:00:00Zhttps://www.dovepress.com/multimodal-evaluation-of-visual-function-in-geographic-atrophy-versus--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Noemi Burguera-Giménez,1– 3 Santiago García-Lázaro,2 Enrique España-Gregori,4,5 Roberto Gallego-Pinazo,6 Neus Burguera-Giménez,2 Manuel Rodríguez-Vallejo,3 Gowtham Jonna1 1Ophthalmology Department, Retina Research Center, Austin, Texas, USA; 2Optometry Department, University of Valencia, Valencia, Spain; 3Ophthalmology Department, Qvision, Hospital Vithas Virgen Del Mar, Almeria, Spain; 4Ophthalmology Department, La Fe University Hospital, Valencia, Spain; 5Surgery Department, University of Valencia, Valencia, Spain; 6Ophthalmology Department, Oftalvist, IMED Hospital, Valencia, SpainCorrespondence: Gowtham Jonna Tel +1512 454 – 5851Email g_jonna@hotmail.comPurpose: To comprehensively evaluate visual function in eyes with geographic atrophy (GA) as compared to normal eyes.Patients and Methods: Sixty-three eyes from 63 patients ≥ 50 years old were recruited for this observational study; 31 were identified as normal macular health eyes and 32 with GA. Visual function was tested with best corrected visual acuity (BCVA), low luminance visual acuity (LLVA), low luminance deficit (LLD), reading speed, macular integrity microperimetry, fixation stability, and contrast sensitivity function (CSF). Anatomic function was evaluated with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Quality of life and vision were assessed with the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25).Results: Visual function and quality of life are reduced in patients with GA. Moderate and strong correlations in the GA group were found between maximum reading speed (r = 0.787) (p˂0.01), CS spatial frequency 3 cpd (r = 0.441) (p˂0.05), CS spatial frequency 6 cpd (r = 0.524) (p˂0.01), fixation P1 (r = 0.379) (p˂0.05), macular sensitivity (r = 0.484) (p˂0.05) and atrophic area (r = − 0.689) (p˂0.01), and the VFQ-25 composite score.Conclusion: The decreased visual function is reflected in a poor quality of life in patients with GA. Reading speed, contrast sensitivity, fixation, and macular sensitivity are strongly associated with vision-related quality of life. The results suggest the importance of the reading letter size in patients with GA. Microperimetry and reading speed are useful tools to better assess visual impairment in patients with GA.Keywords: geographic atrophy, age-related macular degeneration, reading speed, visual function, quality of lifeBurguera-Giménez NGarcía-Lázaro SEspaña-Gregori EGallego-Pinazo RBurguera-Giménez NRodríguez-Vallejo MJonna GDove Medical Pressarticlegeographic atrophyage-related macular degenerationreading speedvisual functionquality of lifeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1533-1545 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	geographic atrophy age-related macular degeneration reading speed visual function quality of life Ophthalmology RE1-994
spellingShingle	geographic atrophy age-related macular degeneration reading speed visual function quality of life Ophthalmology RE1-994 Burguera-Giménez N García-Lázaro S España-Gregori E Gallego-Pinazo R Burguera-Giménez N Rodríguez-Vallejo M Jonna G Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
description	Noemi Burguera-Giménez,1– 3 Santiago García-Lázaro,2 Enrique España-Gregori,4,5 Roberto Gallego-Pinazo,6 Neus Burguera-Giménez,2 Manuel Rodríguez-Vallejo,3 Gowtham Jonna1 1Ophthalmology Department, Retina Research Center, Austin, Texas, USA; 2Optometry Department, University of Valencia, Valencia, Spain; 3Ophthalmology Department, Qvision, Hospital Vithas Virgen Del Mar, Almeria, Spain; 4Ophthalmology Department, La Fe University Hospital, Valencia, Spain; 5Surgery Department, University of Valencia, Valencia, Spain; 6Ophthalmology Department, Oftalvist, IMED Hospital, Valencia, SpainCorrespondence: Gowtham Jonna Tel +1512 454 – 5851Email g_jonna@hotmail.comPurpose: To comprehensively evaluate visual function in eyes with geographic atrophy (GA) as compared to normal eyes.Patients and Methods: Sixty-three eyes from 63 patients ≥ 50 years old were recruited for this observational study; 31 were identified as normal macular health eyes and 32 with GA. Visual function was tested with best corrected visual acuity (BCVA), low luminance visual acuity (LLVA), low luminance deficit (LLD), reading speed, macular integrity microperimetry, fixation stability, and contrast sensitivity function (CSF). Anatomic function was evaluated with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Quality of life and vision were assessed with the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25).Results: Visual function and quality of life are reduced in patients with GA. Moderate and strong correlations in the GA group were found between maximum reading speed (r = 0.787) (p˂0.01), CS spatial frequency 3 cpd (r = 0.441) (p˂0.05), CS spatial frequency 6 cpd (r = 0.524) (p˂0.01), fixation P1 (r = 0.379) (p˂0.05), macular sensitivity (r = 0.484) (p˂0.05) and atrophic area (r = − 0.689) (p˂0.01), and the VFQ-25 composite score.Conclusion: The decreased visual function is reflected in a poor quality of life in patients with GA. Reading speed, contrast sensitivity, fixation, and macular sensitivity are strongly associated with vision-related quality of life. The results suggest the importance of the reading letter size in patients with GA. Microperimetry and reading speed are useful tools to better assess visual impairment in patients with GA.Keywords: geographic atrophy, age-related macular degeneration, reading speed, visual function, quality of life
format	article
author	Burguera-Giménez N García-Lázaro S España-Gregori E Gallego-Pinazo R Burguera-Giménez N Rodríguez-Vallejo M Jonna G
author_facet	Burguera-Giménez N García-Lázaro S España-Gregori E Gallego-Pinazo R Burguera-Giménez N Rodríguez-Vallejo M Jonna G
author_sort	Burguera-Giménez N
title	Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
title_short	Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
title_full	Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
title_fullStr	Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
title_full_unstemmed	Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
title_sort	multimodal evaluation of visual function in geographic atrophy versus normal eyes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/dd97357fdfcc4788ac2f11972c3d3a86
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Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes

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