Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

Abstract Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial biological properties that mediate the advancement of...

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Autores principales:	Andrés López-Cortés, Estefanía Abarca, Leonardo Silva, Erick Velastegui, Ariana León-Sosa, Germania Karolys, Francisco Cabrera, Andrés Caicedo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd976388f6c348708cbc867f01e2881d
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spelling	oai:doaj.org-article:dd976388f6c348708cbc867f01e2881d2021-12-02T18:53:09ZIdentification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes10.1038/s41598-021-96750-52045-2322https://doaj.org/article/dd976388f6c348708cbc867f01e2881d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96750-5https://doaj.org/toc/2045-2322Abstract Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial biological properties that mediate the advancement of the disease and affect patient prognosis. These hallmarks have been proposed to overlap with essential features of the WH process. However, common hallmarks and proteins actively participating in both processes have yet to be described. In this work we identify 21 WH proteins strongly linked with solid tumors by integrated TCGA Pan-Cancer and multi-omics analyses. These proteins were associated with eight of the ten described cancer hallmarks, especially avoiding immune destruction. These results show that WH and cancer's common proteins are involved in the microenvironment modification of solid tissues and immune system regulation. This set of proteins, between WH and cancer, could represent key targets for developing therapies.Andrés López-CortésEstefanía AbarcaLeonardo SilvaErick VelasteguiAriana León-SosaGermania KarolysFrancisco CabreraAndrés CaicedoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrés López-Cortés Estefanía Abarca Leonardo Silva Erick Velastegui Ariana León-Sosa Germania Karolys Francisco Cabrera Andrés Caicedo Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
description	Abstract Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial biological properties that mediate the advancement of the disease and affect patient prognosis. These hallmarks have been proposed to overlap with essential features of the WH process. However, common hallmarks and proteins actively participating in both processes have yet to be described. In this work we identify 21 WH proteins strongly linked with solid tumors by integrated TCGA Pan-Cancer and multi-omics analyses. These proteins were associated with eight of the ten described cancer hallmarks, especially avoiding immune destruction. These results show that WH and cancer's common proteins are involved in the microenvironment modification of solid tissues and immune system regulation. This set of proteins, between WH and cancer, could represent key targets for developing therapies.
format	article
author	Andrés López-Cortés Estefanía Abarca Leonardo Silva Erick Velastegui Ariana León-Sosa Germania Karolys Francisco Cabrera Andrés Caicedo
author_facet	Andrés López-Cortés Estefanía Abarca Leonardo Silva Erick Velastegui Ariana León-Sosa Germania Karolys Francisco Cabrera Andrés Caicedo
author_sort	Andrés López-Cortés
title	Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
title_short	Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
title_full	Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
title_fullStr	Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
title_full_unstemmed	Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
title_sort	identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd976388f6c348708cbc867f01e2881d
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Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

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