WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase promotes stalled fork recovery and limits fork hyper-...

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Autores principales:	Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd9a83371d84474f8a570030b092cfce
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spelling	oai:doaj.org-article:dd9a83371d84474f8a570030b092cfce2021-11-14T12:36:21ZWRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells10.1038/s41467-021-26811-w2041-1723https://doaj.org/article/dd9a83371d84474f8a570030b092cfce2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26811-whttps://doaj.org/toc/2041-1723The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase promotes stalled fork recovery and limits fork hyper-degradation in the absence of BRCA2 protection.Arindam DattaKajal BiswasJoshua A. SommersHaley ThompsonSanket AwateClaudia M. NicolaeTanay ThakarGeorge-Lucian MoldovanRobert H. ShoemakerShyam K. SharanRobert M. BroshNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arindam Datta Kajal Biswas Joshua A. Sommers Haley Thompson Sanket Awate Claudia M. Nicolae Tanay Thakar George-Lucian Moldovan Robert H. Shoemaker Shyam K. Sharan Robert M. Brosh WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
description	The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase promotes stalled fork recovery and limits fork hyper-degradation in the absence of BRCA2 protection.
format	article
author	Arindam Datta Kajal Biswas Joshua A. Sommers Haley Thompson Sanket Awate Claudia M. Nicolae Tanay Thakar George-Lucian Moldovan Robert H. Shoemaker Shyam K. Sharan Robert M. Brosh
author_facet	Arindam Datta Kajal Biswas Joshua A. Sommers Haley Thompson Sanket Awate Claudia M. Nicolae Tanay Thakar George-Lucian Moldovan Robert H. Shoemaker Shyam K. Sharan Robert M. Brosh
author_sort	Arindam Datta
title	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
title_short	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
title_full	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
title_fullStr	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
title_full_unstemmed	WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
title_sort	wrn helicase safeguards deprotected replication forks in brca2-mutated cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd9a83371d84474f8a570030b092cfce
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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

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