The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.

Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yarui Du, Bo Liu, Fan Guo, Guifang Xu, Yuqiang Ding, Yong Liu, Xin Sun, Guoliang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd9e486e646b43a5a716cf833d0debe2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd9e486e646b43a5a716cf833d0debe2
record_format	dspace
spelling	oai:doaj.org-article:dd9e486e646b43a5a716cf833d0debe22021-11-18T08:11:59ZThe essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.1932-620310.1371/journal.pone.0047358https://doaj.org/article/dd9e486e646b43a5a716cf833d0debe22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23077600/?tool=EBIhttps://doaj.org/toc/1932-6203Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome. To investigate the physiological role of Mbd5, we generated knockout mice. The Mbd5-deficient mice showed growth retardation, wasting and pre-weaning lethality. The observed growth retardation was associated with the impairment of GH/IGF-1 axis in Mbd5-null pups. Conditional knockout of Mbd5 in the brain resulted in the similar phenotypes as whole body deletion, indicating that Mbd5 functions in the nervous system to regulate postnatal growth. Moreover, the mutant mice also displayed enhanced glucose tolerance and elevated insulin sensitivity as a result of increased insulin signaling, ultimately resulting in disturbed glucose homeostasis and hypoglycemia. These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis.Yarui DuBo LiuFan GuoGuifang XuYuqiang DingYong LiuXin SunGuoliang XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47358 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yarui Du Bo Liu Fan Guo Guifang Xu Yuqiang Ding Yong Liu Xin Sun Guoliang Xu The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
description	Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome. To investigate the physiological role of Mbd5, we generated knockout mice. The Mbd5-deficient mice showed growth retardation, wasting and pre-weaning lethality. The observed growth retardation was associated with the impairment of GH/IGF-1 axis in Mbd5-null pups. Conditional knockout of Mbd5 in the brain resulted in the similar phenotypes as whole body deletion, indicating that Mbd5 functions in the nervous system to regulate postnatal growth. Moreover, the mutant mice also displayed enhanced glucose tolerance and elevated insulin sensitivity as a result of increased insulin signaling, ultimately resulting in disturbed glucose homeostasis and hypoglycemia. These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis.
format	article
author	Yarui Du Bo Liu Fan Guo Guifang Xu Yuqiang Ding Yong Liu Xin Sun Guoliang Xu
author_facet	Yarui Du Bo Liu Fan Guo Guifang Xu Yuqiang Ding Yong Liu Xin Sun Guoliang Xu
author_sort	Yarui Du
title	The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
title_short	The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
title_full	The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
title_fullStr	The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
title_full_unstemmed	The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
title_sort	essential role of mbd5 in the regulation of somatic growth and glucose homeostasis in mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/dd9e486e646b43a5a716cf833d0debe2
work_keys_str_mv	AT yaruidu theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT boliu theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT fanguo theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT guifangxu theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT yuqiangding theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT yongliu theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT xinsun theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT guoliangxu theessentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT yaruidu essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT boliu essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT fanguo essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT guifangxu essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT yuqiangding essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT yongliu essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT xinsun essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice AT guoliangxu essentialroleofmbd5intheregulationofsomaticgrowthandglucosehomeostasisinmice
_version_	1718422077941219328

The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice.

Ejemplares similares