Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

Abstract Hyperactivation of Wnt and Ras-MAPK signalling are common events in development of colorectal adenomas. Further progression from adenoma-to-carcinoma is frequently associated with 20q gain and overexpression of Aurora kinase A (AURKA). Interestingly, AURKA has been shown to further enhance...

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Main Authors: Annika Jacobsen, Linda J. W. Bosch, Sanne R. Martens-de Kemp, Beatriz Carvalho, Anke H. Sillars-Hardebol, Richard J. Dobson, Emanuele de Rinaldis, Gerrit A. Meijer, Sanne Abeln, Jaap Heringa, Remond J. A. Fijneman, K. Anton Feenstra
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/dda70b65d4554e6cb45b72de811ecbd1
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https://doaj.org/article/dda70b65d4554e6cb45b72de811ecbd1

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